Seroatlas · Human Serome Atlas

PPIC

Peptidyl-prolyl cis-trans isomerase C

Also known as: CYPC, PPIC_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P45877
Gene: PPIC
Ensembl: ENSG00000168938
Chromosome: 5
Canonical length: 212 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Secretome location: Intracellular and membrane

OverviewNCBI Gene

The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase)) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. Similar to other PPIases, this protein can bind immunosuppressant cyclosporin A. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

212 residues, UniProt reviewed canonical sequence.

>P45877|PPIC
     1  MGPGPRLLLP LVLCVGLGAL VFSSGAEGFR KRGPSVTAKV FFDVRIGDKD VGRIVIGLFG
    61  KVVPKTVENF VALATGEKGY GYKGSKFHRV IKDFMIQGGD ITTGDGTGGV SIYGETFPDE
   121  NFKLKHYGIG WVSMANAGPD TNGSQFFITL TKPTWLDGKH VVFGKVIDGM TVVHSIELQA
   181  TDGHDRPLTN CSIINSGKID VKTPFVVEIA DW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PPIC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 59 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 59 nTPM
rectum: 47 nTPM
esophagus: 45 nTPM
placenta: 45 nTPM
thyroid gland: 44 nTPM
heart muscle: 43 nTPM

Single-cell type

esophageal apical cells: 657 nCPM
esophageal suprabasal cells: 507 nCPM
decidual stromal cells: 361 nCPM
hepatic stellate cells: 239 nCPM
enterocytes: 170 nCPM
esophageal basal cells: 162 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 20 nTPM
thalamus: 9.3 nTPM
cerebellum: 9.2 nTPM
medulla oblongata: 8.5 nTPM
midbrain: 8.4 nTPM
pons: 8.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.5
gnomAD pLI: 0
gnomAD missense Z: 0.08
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

protein folding

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PPIC as an antibody target. Whether an autoantibody or antibody against PPIC could matter depends on whether native PPIC is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PPIC is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PPIC as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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