Seroatlas · Human Serome Atlas

PPIAL4H

Peptidyl-prolyl cis-trans isomerase A-like 4H

Also known as: PAL4H_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A075B767
Gene
PPIAL4H
Ensembl
ENSG00000270339
Chromosome
1
Canonical length
164 aa
Protein class
Enzymes, Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable cyclosporin A binding activity and peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

164 residues, UniProt reviewed canonical sequence.

>A0A075B767|PPIAL4H
     1  MVNSVVFFDI TVDGKPLGRI SIKLFADKIP KTAENFRALS TGEKGFRYKG SCFHRIIPGF
    61  MCQGGDFTRP NGTDDKSIYG EKFDDENLIR KHTGSGILSM VNAGPNTNGS QLFICTAKTE
   121  WLDGKHVAFG KVKERVNIVE AMEHFGYRNS KTSKKITIAD CGQF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PPIAL4H can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.24
Highest tissue expression
2.3 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 2.3 nTPM
  • spleen: 0.6 nTPM
  • basal ganglia: 0.5 nTPM
  • cerebral cortex: 0.5 nTPM
  • amygdala: 0.4 nTPM
  • hippocampal formation: 0.4 nTPM

Single-cell type

  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM
  • adrenal medulla cells: 0 nCPM
  • alveolar cells type 1: 0 nCPM
  • alveolar cells type 2: 0 nCPM
  • astrocytes: 0 nCPM

Immune cell

  • gdT-cell: 0.1 nTPM
  • MAIT T-cell: 0.1 nTPM
  • neutrophil: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM

Brain region

  • cerebellum: 4.9 nTPM
  • amygdala: 2.9 nTPM
  • cerebral cortex: 2.9 nTPM
  • hypothalamus: 2.9 nTPM
  • white matter: 2.9 nTPM
  • pons: 2.7 nTPM

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PPIAL4H as an antibody target. Whether an autoantibody or antibody against PPIAL4H could matter depends on whether native PPIAL4H is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PPIAL4H is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PPIAL4H as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PPIAL4H. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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