Seroatlas · Human Serome Atlas

PPIAL4G

Peptidyl-prolyl cis-trans isomerase A-like 4G

Also known as: PAL4G_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0DN37
Gene: PPIAL4G
Ensembl: ENSG00000236334
Chromosome: 1
Canonical length: 164 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable cyclosporin A binding activity and peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

164 residues, UniProt reviewed canonical sequence.

>P0DN37|PPIAL4G
     1  MVNSVIFFDI TVDGKPLGRI SIKQFADKIP KTAENFRALS TGEKGFRYKG SCFHRIIPGF
    61  MCQGGDFTHP NGTGDKSIYG EKFDDENLIR KHTGSGILSM ANAGPNTNGS QFFICTAKTE
   121  WLDGKHVAFG KVKERVNIVE AMEHFGYRNS KTSKKITIAD CGQF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PPIAL4G can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.24
Highest tissue expression: 1.6 nTPM

Expression across tissuesHPA

Tissue

small intestine: 1.6 nTPM
duodenum: 1.5 nTPM
adrenal gland: 1.2 nTPM
cerebral cortex: 0.9 nTPM
skin: 0.9 nTPM
appendix: 0.7 nTPM

Single-cell type

renal collecting duct principal cells: 1.1 nCPM
papillary tip epithelial cells: 0.7 nCPM
podocytes: 0.5 nCPM
loop of henle epithelial cells: 0.3 nCPM
nk-cells: 0.3 nCPM
proximal tubule cells: 0.3 nCPM

Immune cell

NK-cell: 2.5 nTPM
memory B-cell: 2.2 nTPM
T-reg: 2.1 nTPM
non-classical monocyte: 1.8 nTPM
naive B-cell: 1.7 nTPM
total PBMC: 1.7 nTPM

Brain region

cerebellum: 5.5 nTPM
basal ganglia: 4.4 nTPM
cerebral cortex: 4.3 nTPM
midbrain: 4 nTPM
amygdala: 3.9 nTPM
hypothalamus: 3.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: -0.95
DepMap mean gene effect: -0.29
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

protein folding

Molecular functions

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PPIAL4G as an antibody target. Whether an autoantibody or antibody against PPIAL4G could matter depends on whether native PPIAL4G is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PPIAL4G is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PPIAL4G as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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