Seroatlas · Human Serome Atlas

PPIAL4E

Peptidyl-prolyl cis-trans isomerase A-like 4E

Also known as: PAL4E_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A075B759
Gene
PPIAL4E
Ensembl
ENSG00000271567
Chromosome
1
Canonical length
164 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable cyclosporin A binding activity and peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

164 residues, UniProt reviewed canonical sequence.

>A0A075B759|PPIAL4E
     1  MVNSVVFFEI TRDGKPLGRI SIKLFADKIP KTAENFRALS TGEKGFRYKG SCFHRIIPGF
    61  MCQGGDFTRP NGTGDKSIYG EKFDDENLIR KHTGSGILSM ANAGPNTNGS QFFICAAKTE
   121  WLDGKHVAFG KVKERVNIVE AMEHFGYRNS KTSKKITIAD CGQF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PPIAL4E can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.24
Highest tissue expression
0.7 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 0.7 nTPM
  • basal ganglia: 0.2 nTPM
  • amygdala: 0.1 nTPM
  • cerebral cortex: 0.1 nTPM
  • hypothalamus: 0.1 nTPM
  • spleen: 0.1 nTPM

Single-cell type

  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM
  • adrenal medulla cells: 0 nCPM
  • alveolar cells type 1: 0 nCPM
  • alveolar cells type 2: 0 nCPM
  • b-cells: 0 nCPM

Immune cell

  • gdT-cell: 0.1 nTPM
  • naive B-cell: 0.1 nTPM
  • NK-cell: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM

Brain region

  • cerebellum: 0.9 nTPM
  • medulla oblongata: 0.8 nTPM
  • pons: 0.6 nTPM
  • basal ganglia: 0.5 nTPM
  • cerebral cortex: 0.5 nTPM
  • amygdala: 0.4 nTPM

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PPIAL4E as an antibody target. Whether an autoantibody or antibody against PPIAL4E could matter depends on whether native PPIAL4E is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PPIAL4E is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PPIAL4E as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PPIAL4E. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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