Seroatlas · Human Serome Atlas

PPIAL4D

Peptidyl-prolyl cis-trans isomerase A-like 4D

Also known as: PAL4D_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
F5H284
Gene
PPIAL4D
Ensembl
ENSG00000289549
Chromosome
1
Canonical length
164 aa
Protein class
Enzymes, Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable cyclosporin A binding activity and peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

164 residues, UniProt reviewed canonical sequence.

>F5H284|PPIAL4D
     1  MVNSVVFFEI TRDGKPLGRI SIKLFADKIP KTAENFRALS TGEKGFRYKG SCFHRIIPGF
    61  MCQGGDFTRP NGTGDKSIYG EKFDDENLIR KHTGSGILSM ANAGPNTNGS QFFICAAKTE
   121  WLDGKHVAFG KVKERVNIVE ATEHFGYRNS KTSKKITIAD CGQF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PPIAL4D can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.24
Highest tissue expression
0 nTPM

Expression across tissuesHPA

Tissue

  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • appendix: 0 nTPM
  • bone marrow: 0 nTPM
  • breast: 0 nTPM
  • cerebral cortex: 0 nTPM

Single-cell type

  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM
  • adrenal medulla cells: 0 nCPM
  • alveolar cells type 1: 0 nCPM
  • alveolar cells type 2: 0 nCPM
  • b-cells: 0 nCPM

Immune cell

  • NK-cell: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • pons: 0.9 nTPM
  • cerebral cortex: 0.6 nTPM
  • amygdala: 0.5 nTPM
  • cerebellum: 0.5 nTPM
  • medulla oblongata: 0.4 nTPM
  • basal ganglia: 0.2 nTPM

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PPIAL4D as an antibody target. Whether an autoantibody or antibody against PPIAL4D could matter depends on whether native PPIAL4D is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PPIAL4D is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PPIAL4D as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PPIAL4D. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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