Seroatlas · Human Serome Atlas

PPIAL4C

Peptidyl-prolyl cis-trans isomerase A-like 4C

Also known as: PAL4C_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A0A0B4J2A2
Gene: PPIAL4C
Ensembl: ENSG00000288867
Chromosome: 1
Canonical length: 164 aa
Protein class: Enzymes, Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable cyclosporin A binding activity and peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

164 residues, UniProt reviewed canonical sequence.

>A0A0B4J2A2|PPIAL4C
     1  MVNSVVFFDI TVDGKPLGRI SIKLFADKIP KTAENFRALS TGEKGFRYKG SCFHRIIPGF
    61  MCQGGDFTRP NGTGDKSIYG EKFDDENLIR KHTGSGILSM ANAGPNTNGS QFFICTAKTE
   121  WLDGKHVAFG KVKERVNIVE AMEHFGYRNS KTSKKITIAD CGQF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PPIAL4C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.24
Highest tissue expression: 1.6 nTPM

Expression across tissuesHPA

Tissue

lymph node: 1.6 nTPM
duodenum: 1.4 nTPM
appendix: 1.1 nTPM
spleen: 1 nTPM
skeletal muscle: 0.8 nTPM
tonsil: 0.6 nTPM

Single-cell type

lactotrophs: 0.2 nCPM
neutrophil progenitors: 0.1 nCPM
t-cells: 0.1 nCPM
adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM

Immune cell

total PBMC: 8.1 nTPM
plasmacytoid DC: 5.9 nTPM
myeloid DC: 5.2 nTPM
memory B-cell: 4.4 nTPM
naive B-cell: 4 nTPM
T-reg: 3.8 nTPM

Brain region

cerebellum: 2 nTPM
cerebral cortex: 1.5 nTPM
hypothalamus: 1.1 nTPM
basal ganglia: 1 nTPM
white matter: 0.9 nTPM
amygdala: 0.8 nTPM

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

protein folding

Molecular functions

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PPIAL4C as an antibody target. Whether an autoantibody or antibody against PPIAL4C could matter depends on whether native PPIAL4C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PPIAL4C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PPIAL4C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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