PPDPF
Pancreatic progenitor cell differentiation and proliferation factor
Also known as: C20orf149, dJ697K14.9, exdpf, PPDPF_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9H3Y8
- Gene
- PPDPF
- Ensembl
- ENSG00000125534
- Chromosome
- 20
- Canonical length
- 114 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Nucleoli,Microtubules
OverviewNCBI Gene
Predicted to be involved in cell differentiation. Predicted to act upstream of or within TORC1 signaling and liver development. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
114 residues, UniProt reviewed canonical sequence.
>Q9H3Y8|PPDPF
1 MAAIPSSGSL VATHDYYRRR LGSTSSNSSC SSTECPGEAI PHPPGLPKAD PGHWWASFFF
61 GKSTLPFMAT VLESAEHSEP PQASSSMTAC GLARDAPRKQ PGGQSSTASA GPPSLocalizationUniProt · AlphaFold · HPA
Whether an antibody against PPDPF can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.68
- Highest tissue expression
- 647 nTPM
Expression across tissuesHPA
Tissue
- esophagus: 647 nTPM
- spinal cord: 524 nTPM
- blood vessel: 490 nTPM
- skin: 477 nTPM
- skeletal muscle: 466 nTPM
- salivary gland: 445 nTPM
Single-cell type
- esophageal apical cells: 18,165 nCPM
- esophageal suprabasal cells: 3,143 nCPM
- enterocytes: 2,720 nCPM
- colonocytes: 2,542 nCPM
- late spermatids: 2,190 nCPM
- breast lactating cells: 1,456 nCPM
Immune cell
- eosinophil: 26 nTPM
- naive B-cell: 5.9 nTPM
- gdT-cell: 5.7 nTPM
- non-classical monocyte: 5.7 nTPM
- T-reg: 5.7 nTPM
- total PBMC: 5.7 nTPM
Brain region
- white matter: 394 nTPM
- pons: 351 nTPM
- medulla oblongata: 344 nTPM
- midbrain: 340 nTPM
- spinal cord: 307 nTPM
- basal ganglia: 303 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.94
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.37
- DepMap mean gene effect
- 0.01
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads PPDPF as an antibody target. Whether an autoantibody or antibody against PPDPF could matter depends on whether native PPDPF is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
PPDPF is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label PPDPF as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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