Seroatlas · Human Serome Atlas

PPCDC

Phosphopantothenoylcysteine decarboxylase

Also known as: COAC_HUMAN, FLJ14585, MDS018

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96CD2
Gene: PPCDC
Ensembl: ENSG00000138621
Chromosome: 15
Canonical length: 204 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Cytosol
Quaternary structure: Homotrimer

OverviewNCBI Gene

Biosynthesis of coenzyme A (CoA) from pantothenic acid (vitamin B5) is an essential universal pathway in prokaryotes and eukaryotes. PPCDC (EC 4.1.1.36), one of the last enzymes in this pathway, converts phosphopantothenoylcysteine to 4-prime-phosphopantetheine (Daugherty et al., 2002 [PubMed 11923312]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

204 residues, UniProt reviewed canonical sequence.

>Q96CD2|PPCDC
     1  MEPKASCPAA APLMERKFHV LVGVTGSVAA LKLPLLVSKL LDIPGLEVAV VTTERAKHFY
    61  SPQDIPVTLY SDADEWEIWK SRSDPVLHID LRRWADLLLV APLDANTLGK VASGICDNLL
   121  TCVMRAWDRS KPLLFCPAMN TAMWEHPITA QQVDQLKAFG YVEIPCVAKK LVCGDEGLGA
   181  MAEVGTIVDK VKEVLFQHSG FQQS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PPCDC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 20 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 20 nTPM
bone marrow: 19 nTPM
adrenal gland: 18 nTPM
esophagus: 18 nTPM
spleen: 18 nTPM
kidney: 17 nTPM

Single-cell type

neutrophils: 479 nCPM
esophageal apical cells: 159 nCPM
rod photoreceptor cells: 131 nCPM
sertoli cells: 109 nCPM
plasma cells: 103 nCPM
pdcs: 95 nCPM

Immune cell

eosinophil: 154 nTPM
neutrophil: 140 nTPM
non-classical monocyte: 72 nTPM
plasmacytoid DC: 72 nTPM
intermediate monocyte: 66 nTPM
basophil: 48 nTPM

Brain region

white matter: 16 nTPM
cerebral cortex: 15 nTPM
medulla oblongata: 14 nTPM
midbrain: 14 nTPM
choroid plexus: 14 nTPM
basal ganglia: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.38
gnomAD pLI: 0
gnomAD missense Z: 0.43
DepMap mean gene effect: -0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

coenzyme A biosynthetic process

Molecular functions

FMN binding
identical protein binding
phosphopantothenoylcysteine decarboxylase activity

Cellular components

cytosol
phosphopantothenoylcysteine decarboxylase complex

Protein domainsUniProt · Pfam · InterPro

Flavoprotein
Flavin prenyltransferase-like
Flavoprotein

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PPCDC as an antibody target. Whether an autoantibody or antibody against PPCDC could matter depends on whether native PPCDC is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PPCDC is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PPCDC as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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