Seroatlas · Human Serome Atlas

PPAN

Suppressor of SWI4 1 homolog

Also known as: BXDC3, SSF, SSF1, SSF1_HUMAN, SSF2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NQ55
Gene: PPAN
Ensembl: ENSG00000130810
Chromosome: 19
Canonical length: 473 aa
Protein class: Plasma proteins, Predicted intracellular proteins

OverviewNCBI Gene

The protein encoded by this gene is an evolutionarily conserved protein similar to yeast SSF1 as well as to the gene product of the Drosophila gene peter pan (ppan). SSF1 is known to be involved in the second step of mRNA splicing. Both SSF1 and ppan are essential for cell growth and proliferation. Exogenous expression of this gene was reported to reduce the anchorage-independent growth of some tumor cells. Read-through transcription of this gene with P2RY11/P2Y(11), an adjacent downstream gene that encodes an ATP receptor, has been found. These read-through transcripts are ubiquitously present and up-regulated during granulocyte differentiation. [provided by RefSeq, Nov 2010]

Canonical amino-acid sequenceUniProt

473 residues, UniProt reviewed canonical sequence.

>Q9NQ55|PPAN
     1  MGQSGRSRHQ KRARAQAQLR NLEAYAANPH SFVFTRGCTG RNIRQLSLDV RRVMEPLTAS
    61  RLQVRKKNSL KDCVAVAGPL GVTHFLILSK TETNVYFKLM RLPGGPTLTF QVKKYSLVRD
   121  VVSSLRRHRM HEQQFAHPPL LVLNSFGPHG MHVKLMATMF QNLFPSINVH KVNLNTIKRC
   181  LLIDYNPDSQ ELDFRHYSIK VVPVGASRGM KKLLQEKFPN MSRLQDISEL LATGAGLSES
   241  EAEPDGDHNI TELPQAVAGR GNMRAQQSAV RLTEIGPRMT LQLIKVQEGV GEGKVMFHSF
   301  VSKTEEELQA ILEAKEKKLR LKAQRQAQQA QNVQRKQEQR EAHRKKSLEG MKKARVGGSD
   361  EEASGIPSRT ASLELGEDDD EQEDDDIEYF CQAVGEAPSE DLFPEAKQKR LAKSPGRKRK
   421  RWEMDRGRGR LCDQKFPKTK DKSQGAQARR GPRGASRDGG RGRGRGRPGK RVA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PPAN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 32 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 32 nTPM
esophagus: 28 nTPM
skin: 28 nTPM
spleen: 26 nTPM
liver: 24 nTPM
pancreas: 23 nTPM

Single-cell type

brain excitatory neurons: 8.4 nCPM
other brain neurons: 8.1 nCPM
microglia: 7.5 nCPM
brain inhibitory neurons: 6.8 nCPM
oligodendrocytes: 5.6 nCPM
bergmann glia: 5.2 nCPM

Immune cell

naive B-cell: 21 nTPM
memory B-cell: 17 nTPM
naive CD4 T-cell: 13 nTPM
memory CD8 T-cell: 11 nTPM
T-reg: 9.6 nTPM
memory CD4 T-cell: 9.2 nTPM

Brain region

white matter: 32 nTPM
cerebral cortex: 30 nTPM
cerebellum: 29 nTPM
thalamus: 28 nTPM
basal ganglia: 27 nTPM
hippocampal formation: 27 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PPAN.

Disease | ImmuneIEDB

Conditions an epitope on PPAN was assayed in.

melanoma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.16
gnomAD pLI: 0
gnomAD missense Z: -1.77
DepMap mean gene effect: -1.1
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

LSU-rRNA)
maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA
5.8S rRNA

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Brix domain
Brix domain
Protein Peter Pan-like

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PPAN as an antibody target. Whether an autoantibody or antibody against PPAN could matter depends on whether native PPAN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PPAN is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PPAN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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