Seroatlas · Human Serome Atlas

PP2D1

Protein phosphatase 2C-like domain-containing protein 1

Also known as: C3orf48, FLJ25449, PP2D1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A8MPX8
Gene
PP2D1
Ensembl
ENSG00000183977
Chromosome
3
Canonical length
630 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Intermediate filaments

OverviewNCBI Gene

Predicted to enable protein serine/threonine phosphatase activity. Predicted to be involved in negative regulation of MAPK cascade and signal transduction. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

630 residues, UniProt reviewed canonical sequence.

>A8MPX8|PP2D1
     1  MSTNNALRVF WKSREWNMKT STFDSDEDIL LLPKRKRFRK KKSRPVRHTK RHEEEQVYEQ
    61  GTTLPCSICK HEIDLTGIFL HKKQHVALAT LGFQWMGRKK PQPSVIAVQR QFMISKLLSS
   121  FMFTEKTLQS INNAFELLWK KQIPAYYKIF DNIDRSVIYS QKICHLLIKG VGICEDRNST
   181  WKADMNDKFT VVSNFGNKPN VCFFGLFDGH HGASAAELTS MELPVLLLHQ LSKFDPSYQM
   241  TTDEQQIINS FYTVFREEYA AIEDLFSAIN KTEAVRCEYE DTHKAFAKAF WRMDRLLGLG
   301  RKEVSRVQWS GCSAVTCILE GKPKSPYAHK NWKRKNTHDG LAESSPSQEM PKIISGILHV
   361  ANTGNVQAVL CRNGKGFCLT KEHTTRNTNE RRRILQNGAV ISSNEPYGLV EGQVKTTRGL
   421  GFHGNLKLKK SIIPAPQTIS VPIDDLCQFL IVATNGLWEV LDKEEVTALA MTTFHMYKET
   481  YCPIIPNKSP SKGPLLFSTS EPNLTKSQSN IHVLFQYKSV SEVRVSTTNS KENLSDSNYS
   541  KYCIYNPENV ETFPAETTHR KPCSEKVTDR PTSVNDVATN EKESDTKSFY EGAAEYVSHE
   601  LVNAALLAGS RDNITVMVIF LNGSEYQLLT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PP2D1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
6.9 nTPM

Expression across tissuesHPA

Tissue

  • testis: 6.9 nTPM
  • bone marrow: 1.8 nTPM
  • cerebellum: 0.3 nTPM
  • retina: 0.3 nTPM
  • cerebral cortex: 0.2 nTPM
  • lung: 0.2 nTPM

Single-cell type

  • early spermatids: 527 nCPM
  • late spermatids: 476 nCPM
  • late primary spermatocytes: 223 nCPM
  • epicardial cells: 127 nCPM
  • cardiomyocytes: 60 nCPM
  • salivary acinar cells: 28 nCPM

Immune cell

  • eosinophil: 0.1 nTPM
  • naive CD4 T-cell: 0.1 nTPM
  • neutrophil: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • gdT-cell: 0 nTPM

Brain region

  • cerebellum: 2.1 nTPM
  • cerebral cortex: 1.6 nTPM
  • pons: 1.5 nTPM
  • white matter: 1.5 nTPM
  • medulla oblongata: 1.3 nTPM
  • midbrain: 1.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.12
gnomAD pLI
0
gnomAD missense Z
1.13
DepMap mean gene effect
0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PP2D1 as an antibody target. Whether an autoantibody or antibody against PP2D1 could matter depends on whether native PP2D1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PP2D1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PP2D1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PP2D1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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