Seroatlas · Human Serome Atlas

POTEM

Putative POTE ankyrin domain family member M

Also known as: ACT, P704P, POTE14beta, POTEM_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NI47
Gene: POTEM
Ensembl: ENSG00000222036
Chromosome: 14
Canonical length: 508 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

508 residues, UniProt reviewed canonical sequence.

>A6NI47|POTEM
     1  MVAEAGSMPA ASSVKKPFGL RSKMGKWCRH CFPWCRGSGK SNVGTSGDHD DSAMKTLRSK
    61  MGKWCRHCFP WCRGSGKSNV GTSGDHDDSA MKTLRSKMGK WCCHCFPCCR GSGKSKVGPW
   121  GDYDDSAFME PRYHVRREDL DKLHRAAWWG KVPRKDLIVM LKDTDMNKKD KQKRTALHLA
   181  SANGNSEVVK LLLDRRCQLN ILDNKKRTAL TKAVQCQEDE CALMLLEHGT DPNIPDEYGN
   241  TALHYAIYNE DKLMAKALLL YGADIESKNK HGLTPLLLGV HEQKQQVVKF LIKKKANLNA
   301  LDRYGRTVLI LAVCCGSASI VSLLLEQNID VSSQDLSGQT AREYAVSSRH NVICQLLSDY
   361  KEKQILKVSS ENSNPEQDLK LTSEEESQRL KGSENSQPEE MSQEPEINKG GDRKVEEEMK
   421  KHGSTHMGFP ENLPNGATAD NGDDGLIPPR KSRTPESQQF PDTENEQYHS DEQNDTQKQL
   481  SEEQNTGILQ DEILIHEEKQ IEVAENEF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against POTEM can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 18 nTPM

Expression across tissuesHPA

Tissue

prostate: 18 nTPM
testis: 5.4 nTPM
retina: 0.8 nTPM
thyroid gland: 0.5 nTPM
skin: 0.4 nTPM
breast: 0.3 nTPM

Single-cell type

prostatic glandular cells: 96 nCPM
undifferentiated spermatogonia: 3.6 nCPM
sertoli cells: 3.4 nCPM
early primary spermatocytes: 2.3 nCPM
late primary spermatocytes: 1.6 nCPM
basal prostatic cells: 0.6 nCPM

Immune cell

basophil: 0.4 nTPM
memory B-cell: 0.3 nTPM
neutrophil: 0.2 nTPM
classical monocyte: 0.1 nTPM
eosinophil: 0.1 nTPM
gdT-cell: 0.1 nTPM

Brain region

medulla oblongata: 5.4 nTPM
basal ganglia: 5.3 nTPM
cerebral cortex: 5.3 nTPM
white matter: 5.3 nTPM
hypothalamus: 5.2 nTPM
pons: 5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.49
gnomAD pLI: 0
gnomAD missense Z: -0.13
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads POTEM as an antibody target. Whether an autoantibody or antibody against POTEM could matter depends on whether native POTEM is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

POTEM is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label POTEM as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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