Seroatlas · Human Serome Atlas

POTEH

POTE ankyrin domain family member H

Also known as: A26C3, ACTBL1, CT104.7, POTE22, POTEH_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6S545
Gene: POTEH
Ensembl: ENSG00000198062
Chromosome: 22
Canonical length: 545 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

545 residues, UniProt reviewed canonical sequence.

>Q6S545|POTEH
     1  MVAEAGSMPA ASSVKKPFGL RSKMGKWCRH CFAWCRGSGK SNVGTSGDHD DSAMKTLRSK
    61  MGKWCCHCFP WCRGSGKSNV GTSGDHDDSA MKTLRSKMGK WCCHCFPCCR GSGKSNVGTS
   121  GDHDDSAMKT LRSKMGKWCC HCFPCCRGSG KNKVGPWGDY DDSAFMEPRY HVRREDLDKL
   181  HRAAWWGKVP RKDLIVMLKD TDMNKKDKQK RTALHLASAN GNSEVVKLLL DRRCQLNILD
   241  NKKRTALTKA VQCQEDECAL MLLEHGTDPN IPDEYGNTAL HYAIYNEDKL MAKALLLYGA
   301  DIESKNKHGL TPLLLGVHEQ KQQVVKFLIK KKANLNALDR YGRTALILAV CCGSASIVSL
   361  LLEQNIDVSS QDLSGQTARE YAVSSRHNVI CQLLSDYKEK QILKVSSENS NPEQDLKLTS
   421  EEESQRLKGS ENSQPEEMSQ EPEINKGGDR KVEEEMKKHG STHMGFPENL TNGATADNGD
   481  DGLIPPRKSR TPESQQFPDT ENEQYHSDEQ NDTQKQLSEE QNTGILQDEI LIHEEKQIEV
   541  AENEF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against POTEH can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 1.5 nTPM

Expression across tissuesHPA

Tissue

prostate: 1.5 nTPM
testis: 0.8 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM

Single-cell type

prostatic glandular cells: 62 nCPM
undifferentiated spermatogonia: 7.1 nCPM
early primary spermatocytes: 2.3 nCPM
sertoli cells: 1.7 nCPM
differentiating spermatogonia: 1.4 nCPM
late primary spermatocytes: 1.2 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.67
gnomAD pLI: 0
gnomAD missense Z: -0.09
DepMap mean gene effect: -0.22
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads POTEH as an antibody target. Whether an autoantibody or antibody against POTEH could matter depends on whether native POTEH is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

POTEH is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label POTEH as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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