Seroatlas · Human Serome Atlas

POTED

POTE ankyrin domain family member D

Also known as: A26B3, ANKRD21, CT104.1, POTE, POTE-21, POTE21, POTED_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86YR6
Gene: POTED
Ensembl: ENSG00000166351
Chromosome: 21
Canonical length: 584 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

584 residues, UniProt reviewed canonical sequence.

>Q86YR6|POTED
     1  MVAEVCSMPT ASTVKKPFDL RSKMGKWCHH RFPCCRGSGK SNMGTSGDHD DSFMKMLRSK
    61  MGKCCRHCFP CCRGSGTSNV GTSGDHENSF MKMLRSKMGK WCCHCFPCCR GSGKSNVGAW
   121  GDYDHSAFME PRYHIRREDL DKLHRAAWWG KVPRKDLIVM LRDTDMNKRD KEKRTALHLA
   181  SANGNSEVVQ LLLDRRCQLN VLDNKKRTAL IKAIQCQEDE CVLMLLEHGA DRNIPDEYGN
   241  TALHYAIYNE DKLMAKALLL YGADIESKNK CGLTPLLLGV HEQKQQVVKF LIKKKANLNV
   301  LDRYGRTALI LAVCCGSASI VNLLLEQNVD VSSQDLSGQT AREYAVSSHH HVICELLSDY
   361  KEKQMLKISS ENSNPEQDLK LTSEEESQRL KVSENSQPEK MSQEPEINKD CDREVEEEIK
   421  KHGSNPVGLP ENLTNGASAG NGDDGLIPQR RSRKPENQQF PDTENEEYHS DEQNDTRKQL
   481  SEEQNTGISQ DEILTNKQKQ IEVAEQKMNS ELSLSHKKEE DLLRENSVLQ EEIAMLRLEL
   541  DETKHQNQLR ENKILEEIES VKEKTDKLLR AMQLNEEALT KTNI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against POTED can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 2.8 nTPM

Expression across tissuesHPA

Tissue

testis: 2.8 nTPM
retina: 0.2 nTPM
thyroid gland: 0.2 nTPM
adipose tissue: 0.1 nTPM
adrenal gland: 0.1 nTPM
heart muscle: 0.1 nTPM

Single-cell type

early primary spermatocytes: 2.9 nCPM
undifferentiated spermatogonia: 2.5 nCPM
late primary spermatocytes: 1.5 nCPM
differentiating spermatogonia: 1.2 nCPM
late spermatids: 0.7 nCPM
prostatic hillock cells: 0.6 nCPM

Immune cell

basophil: 0.3 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

pons: 1.5 nTPM
cerebral cortex: 1.4 nTPM
hypothalamus: 1.4 nTPM
medulla oblongata: 1.3 nTPM
midbrain: 1.3 nTPM
amygdala: 1.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.8
gnomAD pLI: 0
gnomAD missense Z: 0.63
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads POTED as an antibody target. Whether an autoantibody or antibody against POTED could matter depends on whether native POTED is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

POTED is annotated at the cell surface, where native POTED is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label POTED as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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