Seroatlas · Human Serome Atlas

POTEC

POTE ankyrin domain family member C

Also known as: A26B2, CT104.6, DKFZp686J0529, POTE-18, POTE18, POTEC_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: B2RU33
Gene: POTEC
Ensembl: ENSG00000183206
Chromosome: 18
Canonical length: 542 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for POTEC in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

542 residues, UniProt reviewed canonical sequence.

>B2RU33|POTEC
     1  MVTEVCSMPA ASAVKKPFDL RSKMGKWFHH RFPCCKGSGK SNMGTSGDHD DSFMKMLRSK
    61  MGKCCHHCFP CCRGSGTSNV GTSGDHDNSF MKTLRSKMGK WCCHCFPCCR GSGKSNVGAW
   121  GDYDDSAFME PRYHVRREDL DKLHRAAWWG KVPRKDLIVM LRDTDMNKRD KQKRTALHLA
   181  SANGNSEVVQ LLLDRRCQLN VLDNKKRTAL IKAVQCQEDE CVLMLLEHGA DQNIPDEYGN
   241  TTLHYAVHNE DKLMAKALLL YGADIESKNK CGLTPLLLGV HEQKQQVVKF LIKKKANLNA
   301  LDRYGRTALI LAVCCGSASI VNLLLEQNVD VSSQDLSGQT AREYAVSSHH HVICELLSDY
   361  KEKQMLKISS ENSNPEQDLK LTSEEESQRL KVSENSQPEK MSQEPEINKD CDREVEEEIK
   421  KHGSNPVGLP ENLTNGASAG NGDDGLIPQR RSRKPENQQF PDTENEEYHS DEQNDTRKQL
   481  SEEQNTGISQ DEILTNKQKQ IEVAEKKMNS ELSLSHKKEE DLLRENSMLQ EEIAMLISGD
   541  WN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against POTEC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 1.8 nTPM

Expression across tissuesHPA

Tissue

testis: 1.8 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM

Single-cell type

early primary spermatocytes: 24 nCPM
late primary spermatocytes: 15 nCPM
undifferentiated spermatogonia: 7.6 nCPM
differentiating spermatogonia: 4.4 nCPM
epicardial cells: 2.3 nCPM
late spermatids: 1.9 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

medulla oblongata: 0.1 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.26
gnomAD pLI: 0
gnomAD missense Z: -0.87
DepMap mean gene effect: 0.2
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads POTEC as an antibody target. Whether an autoantibody or antibody against POTEC could matter depends on whether native POTEC is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

POTEC is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label POTEC as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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