Seroatlas · Human Serome Atlas

POTEB3

POTE ankyrin domain family member B3

Also known as: POTB3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A0JP26
Gene: POTEB3
Ensembl: ENSG00000278522
Chromosome: 15
Canonical length: 581 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for POTEB3 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

581 residues, UniProt reviewed canonical sequence.

>A0JP26|POTEB3
     1  MVAEVCSMPA ASAVKKPFDL RSKMGKWCHH RFPCCRGSGK SNMGTSGDHD DSFMKTLRSK
    61  MGKCCHHCFP CCRGSGTSNV GTSGDHDNSF MKTLRSKMGK WCCHCFPCCR GSGKSNVGTW
   121  GDYDDSAFME PRYHVRREDL DKLHRAAWWG KVPRKDLIVM LRDTDMNKRD KQKRTALHLA
   181  SANGNSEVVQ LLLDRRCQLN VLDNKKRTAL IKAVQCQEDE CVLMLLEHGA DGNIQDEYGN
   241  TALHYAIYNE DKLMAKALLL YGADIESKNK CGLTPLLLGV HEQKQQVVKF LIKKKANLNA
   301  LDRYGRTALI LAVCCGSASI VNLLLEQNVD VSSQDLSGQT AREYAVSSHH HVICELLSDY
   361  KEKQMLKISS ENSNPEQDLK LTSEEESQRL KVSENSQPEK MSQEPEINKD CDREVEEEIK
   421  KHGSNPVGLP ENLTNGASAG NGDDGLIPQR KSRKPENQQF PDTENEEYHS DEQNDTQKQL
   481  SEEQNTGISQ DEILTNKQKQ IEVAEKEMNS KLSLSHKKEE DLLRENSMLR EEIAMLRLEL
   541  DETKHQNQLR ENKILEEIES VKEKLLKAIQ LNEEALTKTS I

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against POTEB3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 4.8 nTPM

Expression across tissuesHPA

Tissue

testis: 4.8 nTPM
skin: 0.2 nTPM
thyroid gland: 0.2 nTPM
adipose tissue: 0.1 nTPM
bone marrow: 0.1 nTPM
epididymis: 0.1 nTPM

Single-cell type

early primary spermatocytes: 0.6 nCPM
late primary spermatocytes: 0.4 nCPM
prostatic glandular cells: 0.2 nCPM
bergmann glia: 0.1 nCPM
adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM

Immune cell

basophil: 0.1 nTPM
neutrophil: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

white matter: 3.5 nTPM
cerebral cortex: 3.4 nTPM
hypothalamus: 3.2 nTPM
cerebellum: 3 nTPM
pons: 3 nTPM
medulla oblongata: 2.9 nTPM

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads POTEB3 as an antibody target. Whether an autoantibody or antibody against POTEB3 could matter depends on whether native POTEB3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

POTEB3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label POTEB3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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