Seroatlas · Human Serome Atlas

POTEB

POTE ankyrin domain family member B

Also known as: A26B1, CT104.5, POTE-15, POTE15, POTEB_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A0A0A6YYL3
Gene: POTEB
Ensembl: ENSG00000233917
Chromosome: 15
Canonical length: 544 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for POTEB in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

544 residues, UniProt reviewed canonical sequence.

>A0A0A6YYL3|POTEB
     1  MVAEVCSMPA ASAVKKPFDL RSKMGKWCHH RFPCCRGSGT SNVGTSGDHD DSFMKTLRSK
    61  MGKWCCHCFP CCRGSGKSNV GTWGDYDDSA FMEPRYHVRR EDLDKLHRAA WWGKVPRKDL
   121  IVMLRDTDMN KRDKQKRTAL HLASANGNSE VVQLLLDRRC QLNVLDNKKR TALIKAVQCQ
   181  EDECVLMLLE HGADGNIQDE YGNTALHYAI YNEDKLMAKA LLLYGADIES KNKCGLTPLL
   241  LGVHEQKQEV VKFLIKKKAN LNALDRYGRT ALILAVCCGS ASIVNLLLEQ NVDVSSQDLS
   301  GQTAREYAVS SHHHVICELL SDYKEKQMLK ISSENSNPEQ DLKLTSEEES QRLKVSENSQ
   361  PEKMSQEPEI NKDCDREVEE EIKKHGSNPV GLPENLTNGA SAGNGDDGLI PQRKSRKPEN
   421  QQFPDTENEE YHSDEQNDTQ KQLSEEQNTG ISQDEILTNK QKQIEVAEKE MNSELSLSHK
   481  KEEDLLRENS MLREEIAKLR LELDETKHQN QLRENKILEE IESVKEKLLK TIQLNEEALT
   541  KTSI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against POTEB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 1.1 nTPM

Expression across tissuesHPA

Tissue

testis: 1.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM

Single-cell type

late primary spermatocytes: 0.3 nCPM
adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM
alveolar cells type 1: 0 nCPM
alveolar cells type 2: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.81
gnomAD pLI: 0.35
gnomAD missense Z: -0.67

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads POTEB as an antibody target. Whether an autoantibody or antibody against POTEB could matter depends on whether native POTEB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

POTEB is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label POTEB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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