POSTN

Protein identityUniProt · HPA

UniProt accession

Q15063

Gene

POSTN

Ensembl

ENSG00000133110

Chromosome

13

Canonical length

836 aa

Protein class

Cancer-related genes, Plasma proteins, Predicted secreted proteins

Subcellular location

Golgi apparatus

Secretome location

Secreted to extracellular matrix

Quaternary structure

Homodimer

OverviewNCBI Gene

This gene encodes a secreted extracellular matrix protein that functions in tissue development and regeneration, including wound healing, and ventricular remodeling following myocardial infarction. The encoded protein binds to integrins to support adhesion and migration of epithelial cells. This protein plays a role in cancer stem cell maintenance and metastasis. Mice lacking this gene exhibit cardiac valve disease, and skeletal and dental defects. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]

Canonical amino-acid sequenceUniProt

836 residues, UniProt reviewed canonical sequence.

>Q15063|POSTN
     1  MIPFLPMFSL LLLLIVNPIN ANNHYDKILA HSRIRGRDQG PNVCALQQIL GTKKKYFSTC
    61  KNWYKKSICG QKTTVLYECC PGYMRMEGMK GCPAVLPIDH VYGTLGIVGA TTTQRYSDAS
   121  KLREEIEGKG SFTYFAPSNE AWDNLDSDIR RGLESNVNVE LLNALHSHMI NKRMLTKDLK
   181  NGMIIPSMYN NLGLFINHYP NGVVTVNCAR IIHGNQIATN GVVHVIDRVL TQIGTSIQDF
   241  IEAEDDLSSF RAAAITSDIL EALGRDGHFT LFAPTNEAFE KLPRGVLERI MGDKVASEAL
   301  MKYHILNTLQ CSESIMGGAV FETLEGNTIE IGCDGDSITV NGIKMVNKKD IVTNNGVIHL
   361  IDQVLIPDSA KQVIELAGKQ QTTFTDLVAQ LGLASALRPD GEYTLLAPVN NAFSDDTLSM
   421  DQRLLKLILQ NHILKVKVGL NELYNGQILE TIGGKQLRVF VYRTAVCIEN SCMEKGSKQG
   481  RNGAIHIFRE IIKPAEKSLH EKLKQDKRFS TFLSLLEAAD LKELLTQPGD WTLFVPTNDA
   541  FKGMTSEEKE ILIRDKNALQ NIILYHLTPG VFIGKGFEPG VTNILKTTQG SKIFLKEVND
   601  TLLVNELKSK ESDIMTTNGV IHVVDKLLYP ADTPVGNDQL LEILNKLIKY IQIKFVRGST
   661  FKEIPVTVYT TKIITKVVEP KIKVIEGSLQ PIIKTEGPTL TKVKIEGEPE FRLIKEGETI
   721  TEVIHGEPII KKYTKIIDGV PVEITEKETR EERIITGPEI KYTRISTGGG ETEETLKKLL
   781  QEEVTKVTKF IEGGDGHLFE DEEIKRLLQG DTPVRKLQAN KKVQGSRRRL REGRSQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against POSTN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.32

Highest tissue expression

196 nTPM

Expression across tissuesHPA

ReferencesPubMed · IEDB

Publications for POSTN from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.73

gnomAD pLI

0

gnomAD missense Z

0.85

DepMap mean gene effect

-0.03

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• bone regeneration
• cell adhesion
• cellular response to fibroblast growth factor stimulus
• cellular response to transforming growth factor beta stimulus
• cellular response to tumor necrosis factor
• cellular response to vitamin K
• extracellular matrix organization
• negative regulation of cell-matrix adhesion
• negative regulation of substrate adhesion-dependent cell spreading
• neuron projection extension
• positive regulation of chemokine (C-X-C motif) ligand 2 production
• positive regulation of smooth muscle cell migration
• regulation of Notch signaling pathway
• regulation of systemic arterial blood pressure
• response to estradiol
• response to hypoxia
• response to mechanical stimulus
• response to muscle activity
• tissue development

Molecular functions

• cell adhesion molecule binding
• heparin binding
• metal ion binding

Cellular components

• extracellular matrix
• extracellular space
• neuromuscular junction
• trans-Golgi network

Protein domainsUniProt · Pfam · InterPro

• FAS1 domain
• EMI domain
• TGF beta-induced protein/periostin
• FAS1 domain superfamily
• Cell adhesion and biosynthesis-related protein
• Fasciclin domain

KeywordsUniProt

• Cell adhesion
• Disulfide bond
• Extracellular matrix
• Gamma-carboxyglutamic acid
• Glycoprotein
• Golgi apparatus
• Heparin-binding
• Repeat
• Secreted
• Signal

InteractionsUniProt · HPA

Protein binding partners of POSTN in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• BMP1