Seroatlas · Human Serome Atlas

POPDC3

Popeye domain-containing protein 3

Also known as: bA355M14.1, MGC22671, POP3, POPD3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9HBV1
Gene
POPDC3
Ensembl
ENSG00000132429
Chromosome
6
Canonical length
291 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nucleoli,Cytosol

OverviewNCBI Gene

This gene encodes a member of the POP family of proteins containing three putative transmembrane domains. This gene is expressed in cardiac and skeletal muscle and may play an important role in these tissues during development. Alternatively spliced transcript variants have been found. [provided by RefSeq, Nov 2008]

Canonical amino-acid sequenceUniProt

291 residues, UniProt reviewed canonical sequence.

>Q9HBV1|POPDC3
     1  MERNSSLWKN LIDEHPVCTT WKQEAEGAIY HLASILFVVG FMGGSGFFGL LYVFSLLGLG
    61  FLCSAVWAWV DVCAADIFSW NFVLFVICFM QFVHIAYQVR SITFAREFQV LYSSLFQPLG
   121  ISLPVFRTIA LSSEVVTLEK EHCYAMQGKT SIDKLSLLVS GRIRVTVDGE FLHYIFPLQF
   181  LDSPEWDSLR PTEEGIFQVT LTAETDCRYV SWRRKKLYLL FAQHRYISRL FSVLIGSDIA
   241  DKLYALNDRV YIGKRYHYDI RLPNFYQMST PEIRRSPLTQ HFQNSRRYCD K

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against POPDC3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
3
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
76 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 76 nTPM
  • tongue: 28 nTPM
  • heart muscle: 19 nTPM
  • cerebral cortex: 7 nTPM
  • hippocampal formation: 5.2 nTPM
  • choroid plexus: 5 nTPM

Single-cell type

  • early spermatids: 140 nCPM
  • myonuclei: 98 nCPM
  • cardiomyocytes: 82 nCPM
  • myosatellite cells: 34 nCPM
  • retinal pigment epithelial cells: 30 nCPM
  • oocytes: 23 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • white matter: 14 nTPM
  • cerebral cortex: 10 nTPM
  • basal ganglia: 8.1 nTPM
  • midbrain: 7.5 nTPM
  • medulla oblongata: 7.2 nTPM
  • spinal cord: 7.2 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about POPDC3.

Disease | AllUniProt

Conditions POPDC3 is implicated in, by any mechanism.

  • Muscular dystrophy, limb-girdle, autosomal recessive 26 (LGMDR26) MIM:618848

Disease | GeneticClinVar

6 pathogenic / likely-pathogenic of 54 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Muscular dystrophy, limb-girdle, autosomal recessive 26

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.9
gnomAD pLI
0.01
gnomAD missense Z
0.67
DepMap mean gene effect
0.08
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads POPDC3 as an antibody target. Whether an autoantibody or antibody against POPDC3 could matter depends on whether native POPDC3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

POPDC3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label POPDC3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/POPDC3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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