Seroatlas · Human Serome Atlas

POPDC2

Popeye domain-containing protein 2

Also known as: POP2, POPD2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9HBU9
Gene: POPDC2
Ensembl: ENSG00000121577
Chromosome: 3
Canonical length: 364 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a member of the POP family of proteins which contain three putative transmembrane domains. This membrane associated protein is predominantly expressed in skeletal and cardiac muscle, and may have an important function in these tissues. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

364 residues, UniProt reviewed canonical sequence.

>Q9HBU9|POPDC2
     1  MSANSSRVGQ LLLQGSACIR WKQDVEGAVY HLANCLLLLG FMGGSGVYGC FYLFGFLSAG
    61  YLCCVLWGWF SACGLDIVLW SFLLAVVCLL QLAHLVYRLR EDTLPEEFDL LYKTLCLPLQ
   121  VPLQTYKEIV HCCEEQVLTL ATEQTYAVEG ETPINRLSLL LSGRVRVSQD GQFLHYIFPY
   181  QFMDSPEWES LQPSEEGVFQ VTLTAETSCS YISWPRKSLH LLLTKERYIS CLFSALLGYD
   241  ISEKLYTLND KLFAKFGLRF DIRLPSLYHV LGPTAADAGP ESEKGDEEVC EPAVSPPQAT
   301  PTSLQQTPPC STPPATTNFP APPTRARLSR PDSGILASRI PLQSYSQVIS RGQAPLAPTH
   361  TPEL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against POPDC2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 378 nTPM

Expression across tissuesHPA

Tissue

heart muscle: 378 nTPM
tongue: 91 nTPM
colon: 90 nTPM
skeletal muscle: 77 nTPM
seminal vesicle: 46 nTPM
urinary bladder: 44 nTPM

Single-cell type

thymic myoid cells: 117 nCPM
smooth muscle cells: 88 nCPM
cardiomyocytes: 82 nCPM
myonuclei: 41 nCPM
mast cells: 15 nCPM
cdc: 12 nCPM

Immune cell

non-classical monocyte: 1.3 nTPM
naive CD4 T-cell: 0.8 nTPM
eosinophil: 0.7 nTPM
T-reg: 0.7 nTPM
basophil: 0.5 nTPM
memory CD4 T-cell: 0.5 nTPM

Brain region

choroid plexus: 2.1 nTPM
cerebellum: 1 nTPM
medulla oblongata: 0.8 nTPM
midbrain: 0.7 nTPM
thalamus: 0.7 nTPM
amygdala: 0.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.08
gnomAD pLI: 0
gnomAD missense Z: 0.23
DepMap mean gene effect: 0.18
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

cAMP binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads POPDC2 as an antibody target. Whether an autoantibody or antibody against POPDC2 could matter depends on whether native POPDC2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

POPDC2 is annotated at the cell surface, where native POPDC2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label POPDC2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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