Seroatlas · Human Serome Atlas

POMZP3

POM121 and ZP3 fusion protein

Also known as: POM-ZP3, POM121, POZP3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6PJE2
Gene: POMZP3
Ensembl: ENSG00000146707
Chromosome: 7
Canonical length: 187 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear membrane

OverviewNCBI Gene

This gene appears to have resulted from a fusion of DNA sequences derived from 2 distinct loci, specifically through the duplication of two internal exons from the POM121 gene and four 3' exons from the ZP3 gene. The 5' end of this gene is similar to the 5` coding region of the POM121 gene which encodes an integral nuclear pore membrane protein. However, the protein encoded by this gene lacks the nuclear pore localization motif. The 3' end of this gene is similar to the last 4 exons of the zona pellucida glycoprotein 3 (ZP3) gene and the encoded protein retains one zona pellucida domain. Multiple protein isoforms are encoded by transcript variants of this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

187 residues, UniProt reviewed canonical sequence.

>Q6PJE2|POMZP3
     1  MVCSPVTLRI APPDRRFSRS AIPEQIISST LSSPSSNAPD PCAKETVLSA LKEKKKKRTV
    61  EEEDQIFLDG QENKRSCLVD GLTDASSAFK VPRPGPDTLQ FTVDVFHFAN DSRNMIYITC
   121  HLKVTLAEQD PDELNKACSF SKPSNSWFPV EGLADICQCC NKGDCGTPSH SRRQPRVVSQ
   181  WSTSASL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against POMZP3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 28 nTPM

Expression across tissuesHPA

Tissue

testis: 28 nTPM
skeletal muscle: 19 nTPM
cerebellum: 16 nTPM
kidney: 16 nTPM
ovary: 16 nTPM
blood vessel: 15 nTPM

Single-cell type

late spermatids: 86 nCPM
oocytes: 83 nCPM
late primary spermatocytes: 51 nCPM
early spermatids: 23 nCPM
epicardial cells: 18 nCPM
other brain neurons: 18 nCPM

Immune cell

eosinophil: 5.9 nTPM
naive B-cell: 3.8 nTPM
naive CD4 T-cell: 3.6 nTPM
memory CD4 T-cell: 3.2 nTPM
memory CD8 T-cell: 3.1 nTPM
myeloid DC: 2.8 nTPM

Brain region

cerebellum: 34 nTPM
white matter: 29 nTPM
cerebral cortex: 28 nTPM
pons: 28 nTPM
medulla oblongata: 27 nTPM
hippocampal formation: 26 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.35
gnomAD pLI: 0
gnomAD missense Z: -0.46
DepMap mean gene effect: -0.27
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads POMZP3 as an antibody target. Whether an autoantibody or antibody against POMZP3 could matter depends on whether native POMZP3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

POMZP3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label POMZP3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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