Seroatlas · Human Serome Atlas

POM121L2

POM121-like protein 2

Also known as: P12L2_HUMAN, POM121-L

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96KW2
Gene: POM121L2
Ensembl: ENSG00000158553
Chromosome: 6
Canonical length: 1035 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable nuclear localization sequence binding activity. Predicted to be a structural constituent of nuclear pore. Predicted to be involved in RNA export from nucleus and protein import into nucleus. Predicted to be part of nuclear pore. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1035 residues, UniProt reviewed canonical sequence.

>Q96KW2|POM121L2
     1  MGSFLSKLEL SPSSPAQVRT DLPERPTKRR PPQPLHQVHR VQFVHRAHPA PRYRPVRRRP
    61  NLDPANPTTW LANEAWRRFP MKKSQNSPLG PLPSDWWESY LKRTIWSLRH PRPIWSPVTI
   121  RITPPDQRVP PSTSPEDVIA LAGLPPSEEL ADPCSKETVL RALRECRKGK GRLEEPLFPE
   181  SLDSKRRSPE TRPSAFKPLM KNGTLTSFVP RPGPLKRSLH SWGSDHSLTK RPNCSSMSSL
   241  ASIYRGGTLS SKRNAIGSSY SSCRNFSDPW KRSVPSVSFE TPEWPIKKEK SCHRPSSPVP
   301  LVSDFESLGG SESSGQQNQK IPQLPSSPEN LVSEIPPPQL GYAVSDENLT LGKKAELQVS
   361  NNAGEDTTEV NTDPFPETWL AIQPSLSLAL PSSETDLTQG ANPQLENLRK MQKSLGPLAS
   421  PQSTGEATSV AHSPLKTPSL PTPPGCSQSE LLPGTSPDSK PTATFILLTP TSPTLPVTDT
   481  TWPPSTSQAD RSPMPPDPPA PPTIQSTLLG MVSSPTSHLS ASAPPDATSA HLMLKPILGP
   541  LHNSEIGSSS YSRISVTAAA SSISSLSTIQ GTLTPTFKPI FGSIDPLKTT PMIAPFSSKQ
   601  TPPPFTHAST HHFHGLVKAT SVVMSTTLAS TSKDSVFKPP LDFGVVNVTS AVGNTYSVPS
   661  TCDTFLLGTA QAFRADFTPA TGFIFPPHHH PTIPTVHTVT MFTQVLSSVV QISPRSSTAN
   721  FRGMGSPLPA SALVSTNWLA STPSISNLTP AITSPLGSSS RPPFPLSQGA NPQPAFGATN
   781  GQKQGPSQPA LMPSVSSSFL FGSSAVALPT PMPTPAQPAF ISTTQSALGC LTPSASTSQT
   841  PASTWSGIGG IPAGFPISQA STTGFRIVIQ THQSGAFGSV FGSRAPQPFT FGGFVTPMDC
   901  DESGIIMTGP DMSPTSGAFS IGALPSGTTN TMIPFGKGWS QNTEGLPSHR TAFSLGRGSI
   961  SARKTMAPIA QNTPVPGQAK AGSSVGFGMP FPPAQGSVGR GPFRSSASSF SIGAKSKTPK
  1021  NREKGHSRRH HAYKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against POM121L2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.71
Highest tissue expression: 7 nTPM

Expression across tissuesHPA

Tissue

testis: 7 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM

Single-cell type

late primary spermatocytes: 22 nCPM
early primary spermatocytes: 8.4 nCPM
gastric progenitor cells: 2.6 nCPM
parietal cells: 1.8 nCPM
cytotrophoblasts: 1.6 nCPM
early spermatids: 1.5 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

basal ganglia: 0.2 nTPM
cerebral cortex: 0.2 nTPM
amygdala: 0.1 nTPM
hippocampal formation: 0.1 nTPM
midbrain: 0.1 nTPM
white matter: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.85
gnomAD pLI: 0.33
gnomAD missense Z: 2.16
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nuclear pore

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads POM121L2 as an antibody target. Whether an autoantibody or antibody against POM121L2 could matter depends on whether native POM121L2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

POM121L2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label POM121L2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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