Seroatlas · Human Serome Atlas

POM121L1P

Putative POM121-like protein 1

Also known as: P12L1_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q3SYA9
Gene: POM121L1P
Canonical length: 428 aa

OverviewNCBI Gene

No narrative summary is available for POM121L1P in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

428 residues, UniProt reviewed canonical sequence.

>Q3SYA9|POM121L1P
     1  MDSLWGPGAG SHPFGVHNSR LSPDLCPGKI VLRALKESGA GMPEQDKDPR VQENPGDQRR
    61  VPEVTGDAPS AFRPLRDNGG LSPFVPGPGP LQTDLHAQRS EIRYNQTSQT SWTSSCTNRN
   121  AISSSYSSTG GLPGLKRRRG PASSHCQLTL SSSKTVSEDR PQAVSSGHTQ CEKVAEIAPG
   181  QTLALRNDSS RSEASRPSTR KFPLLPRRRG EPLMLPPPVE LGYRVTAEDL DWEKEAAFQC
   241  IKSALQVEDK AISDCRPSRP SHTLSSLATG ASGLPAVSKA PSMDAQQERH KSQDCLGLVA
   301  PLASATEVPS TAPMSGEKHR PPGPLFSSSD PLPATSSHSQ DSAQVTSLIP APFPAASMDA
   361  GMRRTRPGTS APAAAAAAPP PSTLNRTLGS LLEWMEALHI SGPQPQLQQV PRGQNQRSQT
   421  SRTSSCPK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against POM121L1P can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.72

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads POM121L1P as an antibody target. Whether an autoantibody or antibody against POM121L1P could matter depends on whether native POM121L1P is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

POM121L1P is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label POM121L1P as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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