Seroatlas · Human Serome Atlas

POM121L12

POM121-like protein 12

Also known as: DKFZp564N2472, P1L12_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8N7R1
Gene
POM121L12
Ensembl
ENSG00000221900
Chromosome
7
Canonical length
296 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for POM121L12 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

296 residues, UniProt reviewed canonical sequence.

>Q8N7R1|POM121L12
     1  MGAAAPAESA DLGNFWKAGE PLLQGPDALA APMSRSPSTP QTTPSPQGRQ SPWPLRSLTQ
    61  SHIQYFQWGR PVPSTHLIEV RPTQDPAKPQ RVVSEGWRRP ALPGETALGR DLSCAWEGCM
   121  KGGLCRAWNP GRTWSPVTIG IAPPERQESP WRSPGQRARP AGRPAAQELL DPCTRETLLG
   181  ALSQCPKGSA RFDGPLWFEV SDSKGGRRNL QPRPSAFKPL SKNGAVASFV PRPGPLKPSL
   241  GPWSLSFCDD AWPSVLVQPA PSAIWDFWEA TTPSCGSCSR VSFALEVTQS AGPFGS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against POM121L12 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.68
Highest tissue expression
12 nTPM

Expression across tissuesHPA

Tissue

  • testis: 12 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM
  • appendix: 0 nTPM
  • basal ganglia: 0 nTPM

Single-cell type

  • late primary spermatocytes: 34 nCPM
  • late spermatids: 3.3 nCPM
  • early primary spermatocytes: 2 nCPM
  • early spermatids: 0.8 nCPM
  • sertoli cells: 0.3 nCPM
  • differentiating spermatogonia: 0.1 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • amygdala: 0 nTPM
  • basal ganglia: 0 nTPM
  • cerebellum: 0 nTPM
  • cerebral cortex: 0 nTPM
  • choroid plexus: 0 nTPM
  • hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z
-1.45
DepMap mean gene effect
0.08
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 1% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads POM121L12 as an antibody target. Whether an autoantibody or antibody against POM121L12 could matter depends on whether native POM121L12 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

POM121L12 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label POM121L12 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/POM121L12. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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