Seroatlas · Human Serome Atlas

POM121C

Nuclear envelope pore membrane protein POM 121C

Also known as: P121C_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A8CG34
Gene
POM121C
Ensembl
ENSG00000272391
Chromosome
7
Canonical length
1229 aa
Protein class
Predicted intracellular proteins, Transporters
Subcellular location
Nucleoplasm,Nuclear membrane

OverviewNCBI Gene

Predicted to enable nuclear localization sequence binding activity. Predicted to be a structural constituent of nuclear pore. Predicted to be involved in RNA export from nucleus and protein import into nucleus. Located in nuclear membrane and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1229 residues, UniProt reviewed canonical sequence.

>A8CG34|POM121C
     1  MSPAAAAAGA GERRRPIASV RDGRGRGCGG PAGAALLGLS LVGLLLYLVP AAAALAWLAV
    61  GTTAAWWGLS REPRGSRPLS SFVQKARHRR TLFASPPAKS TANGNLLEPR TLLEGPDPAE
   121  LLLMGSYLGK PGPPQPAPAP EGQDLRNRPG RRPPARPAPR STPPSQPTHR VHHFYPSLPT
   181  PLLRPSGRPS PRDRGTLPDR FVITPRRRYP IHQTQYSCPG VLPTVCWNGY HKKAVLSPRN
   241  SRMVCSPVTV RIAPPDRRFS RSAIPEQIIS STLSSPSSNA PDPCAKETVL SALKEKKKKR
   301  TVEEEDQIFL DGQENKRRRH DSSGSGHSAF EPLVASGVPA SFVPKPGSLK RGLNSQSSDD
   361  HLNKRSRSSS MSSLTGAYTS GIPSSSRNAI TSSYSSTRGI SQLWKRNGPS SSPFSSPASS
   421  RSQTPERPAK KIREEELCHH SSSSTPLAAD KESQGEKAAD TTPRKKQNSN SQSTPGSSGQ
   481  RKRKVQLLPS RRGEQLTLPP PPQLGYSITA EDLDLEKKAS LQWFNQALED KSDAASNSVT
   541  ETPPTTQPSF TFTLPAAATA SPPTSLLAPS TNPLLESLKK MQTPPSLPPC PESAGAATTE
   601  ALSPPKTPSL LPPLGLSQSG PPGLLPSPSF DSKPPTTLLG LIPAPSMVPA TDTKAPPTLQ
   661  AETATKPQAT SAPSPAPKQS FLFGTQNTSP SSPAAPAASS ASPMFKPIFT APPKSEKEGL
   721  TPPGPSVSAT APSSSSLPTT TSTTAPTFQP VFSSMGPPAS VPLPAPFFKQ TTTPATAPTT
   781  TAPLFTGLAS ATSAVAPITS ASPSTDSASK PAFGFGINSV SSSSVSTTTS TATAASQPFL
   841  FGAPQASAAS FTPAMGSIFQ FGKPPALPTT TTVTTFSQSL PTAVPTATSS SAADFSGFGS
   901  TLATSAPATS SQPTLTFSNT STPTFNIPFG SSAKSPLPSY PGANPQPAFG AAEGQPPGAA
   961  KPALTPSFGS SFTFGNSAAP APATAPTPAP ASTIKIVPAH VPTPIQPTFG GATHSAFGLK
  1021  ATASAFGAPA SSQPAFGGST AVFSFGAATS SGFGATTQTA SSGSSSSVFG STTPSPFTFG
  1081  GSAAPAGSGS FGINVATPGS SATTGAFSFG AGQSGSTATS TPFTGGLGQN ALGTTGQSTP
  1141  FAFNVGSTTE SKPVFGGTAT PTFGQNTPAP GVGTSGSSLS FGASSAPAQG FVGVGPFGSA
  1201  APSFSIGAGS KTPGARQRLQ ARRQHTRKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against POM121C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.72
Highest tissue expression
28 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 28 nTPM
  • retina: 25 nTPM
  • cerebellum: 21 nTPM
  • tonsil: 19 nTPM
  • skeletal muscle: 19 nTPM
  • lymph node: 17 nTPM

Single-cell type

  • myonuclei: 98 nCPM
  • cardiomyocytes: 90 nCPM
  • cone photoreceptor cells: 87 nCPM
  • neutrophils: 80 nCPM
  • proximal tubule cells: 76 nCPM
  • distal convoluted tubule cells: 73 nCPM

Immune cell

  • neutrophil: 1.4 nTPM
  • gdT-cell: 1.2 nTPM
  • plasmacytoid DC: 1.2 nTPM
  • MAIT T-cell: 1 nTPM
  • naive B-cell: 1 nTPM
  • memory CD4 T-cell: 0.9 nTPM

Brain region

  • cerebral cortex: 75 nTPM
  • cerebellum: 66 nTPM
  • hippocampal formation: 64 nTPM
  • hypothalamus: 59 nTPM
  • white matter: 58 nTPM
  • midbrain: 56 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.05
gnomAD pLI
0
gnomAD missense Z
-0.21
DepMap mean gene effect
-0.48
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads POM121C as an antibody target. Whether an autoantibody or antibody against POM121C could matter depends on whether native POM121C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

POM121C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label POM121C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/POM121C. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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