Seroatlas · Human Serome Atlas

POM121B

Putative nuclear envelope pore membrane protein POM 121B

Also known as: P121B_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NF01
Gene: POM121B
Canonical length: 834 aa

OverviewNCBI Gene

No narrative summary is available for POM121B in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

834 residues, UniProt reviewed canonical sequence.

>A6NF01|POM121B
     1  MSRRVRTSEL WKRNGPSSSP FSSPASSRSQ TPERPAKKIR EEEMCHHSSS STPLAADKES
    61  QGEKAADTTP RKKQNSNSQS TPGSSGQRKR KVQLLPSRRG EQLTLPPPPQ LGYSITAEDL
   121  DLEKKASLQW FNQALEDKSD AASNSVTETP PITQPSFTFT LPAAAPASPP TSLLAPSTNP
   181  LLESLKKMQT PPSLPPCPES AGAATTEALS PPKTPNLLPP LGLSQSGPPG LLPSPSFDSN
   241  PPTTLLGLIP APSMVPATDT KAPPTLQAET TTKPQATSAP SPAPKQSFLF GTQNTSPSSP
   301  AAPAASSASP MFKPIFTAPP KSEKEGPTPP GPSVSATAPS SSSLPTTTST TAPTFQPVFS
   361  SMGPPASVPL PAPFFKQTTT PATAPTTTAP LFTGLASATS AVAPITSASP STDSASKPAF
   421  GFGINSVSSS SVSTTTSTAT AASQPFLFGA PQASAASFTP AMGSIFQFGK PPALPTTTTV
   481  TTFSQSLPTA VPTATSSSAA DFSGFGSTLA TSAPATSSQP TLTFSNTSTP TFNIPFGSSA
   541  KSPLPSYPGA NPQPAFGAAE GQPPGAAKPA LTPSFGSSFT FGNSAAPAAA PTPAPPSMIK
   601  IVPAHVPTPI QPTFGGATHS AFGLKATASA FGAPASSQPA FGGSTAVFSF GAATSSGFGA
   661  TTQTASSGSS SSVFGSTTPS PFTFGGSAAP AGSGSFGINV ATPGSSATTG AFSFGAGQSG
   721  STATSTPFAG GLGQNALGTT GQSTPFAFNV GSTTESKPVF GGTATPTFGL NTPAPGVGTS
   781  GSSLSFGASS APAQGFVGVA PFGSAAPSFS IGAGSKTLGA RQRLQARRQH TRKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against POM121B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.73

OntologyGO

Biological processes

Molecular functions

Cellular components

nuclear pore

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads POM121B as an antibody target. Whether an autoantibody or antibody against POM121B could matter depends on whether native POM121B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

POM121B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label POM121B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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