Seroatlas · Human Serome Atlas

POLR2J3

DNA-directed RNA polymerase II subunit RPB11-b2

Also known as: RPB1C_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H1A7
Gene
POLR2J3
Canonical length
115 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for POLR2J3 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

115 residues, UniProt reviewed canonical sequence.

>Q9H1A7|POLR2J3
     1  MNAPPAFESF LLFEGEKITI NKDTKVPNAC LFTINKEDHT LGNIIKSQLL KDPQVLFAGY
    61  KVPHPLEHKI IIRVQTTPDY SPQEAFTNAI TDLISELSLL EERFRTCLLP LRLLP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against POLR2J3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
3.5 nTPM

Expression across tissuesHPA

Tissue

  • skin: 3.5 nTPM
  • cerebral cortex: 3.3 nTPM
  • fallopian tube: 3.3 nTPM
  • salivary gland: 3.1 nTPM
  • duodenum: 3 nTPM
  • cervix: 2.9 nTPM

Single-cell type

  • esophageal apical cells: 2.6 nCPM
  • bergmann glia: 1.2 nCPM
  • ocular epithelial cells: 1.2 nCPM
  • oligodendrocytes: 1.1 nCPM
  • astrocytes: 1 nCPM
  • ependymal cells: 1 nCPM

Immune cell

  • basophil: 8.8 nTPM
  • neutrophil: 7.6 nTPM
  • eosinophil: 5.6 nTPM
  • myeloid DC: 4.2 nTPM
  • classical monocyte: 3.7 nTPM
  • NK-cell: 3.7 nTPM

Brain region

  • hypothalamus: 2.2 nTPM
  • cerebellum: 2 nTPM
  • thalamus: 1.6 nTPM
  • cerebral cortex: 1.5 nTPM
  • medulla oblongata: 1.5 nTPM
  • pons: 1.5 nTPM

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads POLR2J3 as an antibody target. Whether an autoantibody or antibody against POLR2J3 could matter depends on whether native POLR2J3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

POLR2J3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label POLR2J3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/POLR2J3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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