POLR1H
DNA-directed RNA polymerase I subunit RPA12
Also known as: A12.2, HTEX-6, hZR14, RPA12, RPA12_HUMAN, tctex-6, ZNRD1
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9P1U0
- Gene
- POLR1H
- Ensembl
- ENSG00000066379
- Chromosome
- 6
- Canonical length
- 126 aa
- Protein class
- Metabolic proteins, Predicted intracellular proteins, RNA polymerase related proteins
- Subcellular location
- Nucleoli fibrillar center
OverviewNCBI Gene
This gene encodes a DNA-directed RNA polymerase I subunit. The encoded protein contains two potential zinc-binding motifs and may play a role in regulation of cell proliferation. The encoded protein may be involved in cancer and human immunodeficiency virus progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Canonical amino-acid sequenceUniProt
126 residues, UniProt reviewed canonical sequence.
>Q9P1U0|POLR1H
1 MSVMDLANTC SSFQSDLDFC SDCGSVLPLP GAQDTVTCIR CGFNINVRDF EGKVVKTSVV
61 FHQLGTAMPM SVEEGPECQG PVVDRRCPRC GHEGMAYHTR QMRSADEGQT VFYTCTNCKF
121 QEKEDSLocalizationUniProt · AlphaFold · HPA
Whether an antibody against POLR1H can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.47
- Highest tissue expression
- 32 nTPM
Expression across tissuesHPA
Tissue
- spleen: 32 nTPM
- kidney: 30 nTPM
- testis: 30 nTPM
- pancreas: 29 nTPM
- esophagus: 29 nTPM
- adrenal gland: 26 nTPM
Single-cell type
- late primary spermatocytes: 208 nCPM
- early spermatids: 113 nCPM
- megakaryocytes: 93 nCPM
- vascular smooth muscle cells: 85 nCPM
- gastric progenitor cells: 85 nCPM
- epididymal basal cells: 66 nCPM
Immune cell
- basophil: 22 nTPM
- T-reg: 7.8 nTPM
- MAIT T-cell: 6.7 nTPM
- naive CD4 T-cell: 6.6 nTPM
- gdT-cell: 6.5 nTPM
- myeloid DC: 6.3 nTPM
Brain region
- hypothalamus: 4.2 nTPM
- midbrain: 3 nTPM
- medulla oblongata: 2.6 nTPM
- spinal cord: 2.5 nTPM
- thalamus: 2.5 nTPM
- pons: 2.4 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.91
- gnomAD pLI
- 0.21
- DepMap mean gene effect
- -0.87
- DepMap dependency class
- common
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads POLR1H as an antibody target. Whether an autoantibody or antibody against POLR1H could matter depends on whether native POLR1H is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
POLR1H is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label POLR1H as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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