Seroatlas · Human Serome Atlas

POLGARF

POLG alternative reading frame

Also known as: ORF-Y, PLGRF_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A0A3B3IS91
Gene: POLGARF
Ensembl: ENSG00000291307
Chromosome: 15
Canonical length: 260 aa
Protein class: Predicted intracellular proteins, Predicted secreted proteins
Secretome location: Secreted - unknown location

OverviewNCBI Gene

This gene uses the same transcript as the POLG gene but has a CUG start codon and an alternate reading frame that makes a 260 aa protein. This protein is distinct from POLG isoforms and may interact with P32 (also known as C1QBP), a mitochondrial matrix protein thought to be involved in the expression of mitochondrial genome-encoded proteins. POLGARF protein may bind P32 and sequester it in the nucleolus. Interestingly, some disease-causing mutations thought to be in POLG may instead be associated with POLGARF. [provided by RefSeq, May 2022]

Canonical amino-acid sequenceUniProt

260 residues, UniProt reviewed canonical sequence.

>A0A3B3IS91|POLGARF
     1  MEPKARCSDS QRGGPCTNHE PPALEEGGRR HRRARAGSSS GALGLQLRPR VRPQRRAAAA
    61  AAAAAAAAAA ATAASAAASA ILGGRAAAAQ PIGHPDALER AARANLRARR GDAWRGRGAP
   121  QRRAPAEARA LGAASRALAR RGAAPAAPLR GQPGPALPPP GPEAEPALPG GGQLAVAGPA
   181  APEAPGLGLG GGLDPVRPRG GGRTRGHPRG AGPGVRRGGL LGRGNLPHIG GGHIPLGLVF
   241  LVQPAAGGRA LLLDQPAVAG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against POLGARF can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.7
Highest tissue expression: 0.2 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 0.2 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
appendix: 0 nTPM
breast: 0 nTPM
cerebral cortex: 0 nTPM

Single-cell type

adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM
alveolar cells type 1: 0 nCPM
alveolar cells type 2: 0 nCPM
b-cells: 0 nCPM

Immune cell

neutrophil: 3.1 nTPM
basophil: 0.6 nTPM
classical monocyte: 0.1 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

medulla oblongata: 14 nTPM
midbrain: 10 nTPM
amygdala: 8.9 nTPM
white matter: 8.5 nTPM
cerebral cortex: 8.4 nTPM
pons: 8 nTPM

OntologyGO

Cellular components

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of POLGARF in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

C1QBP

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads POLGARF as an antibody target. Whether an autoantibody or antibody against POLGARF could matter depends on whether native POLGARF is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

POLGARF is annotated as secreted, so native POLGARF circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label POLGARF as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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