Seroatlas · Human Serome Atlas

POGLUT2

Protein O-glucosyltransferase 2

Also known as: EP58, KDELC1, MGC5302, PLGT2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6UW63
Gene: POGLUT2
Ensembl: ENSG00000134901
Chromosome: 13
Canonical length: 502 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm
Secretome location: Intracellular and membrane

OverviewNCBI Gene

This gene encodes a protein product localized to the lumen of the endoplasmic reticulum. As a member of the endoplasmic reticulum protein family the encoded protein contains a Lys-Asp-Glu-Leu or KDEL motif located at the extreme C-terminus which prevents all endoplasmic reticulum resident proteins from being secreted. Proteins carrying this motif are bound by a receptor in the Golgi apparatus so that the receptor-ligand complex returns to the endoplasmic reticulum. A processed non-transcribed pseudogene located in an intron of a sodium transporter gene on chromosome 5 has been defined for this gene. This gene has multiple transcript variants which are predicted to encode distinct isoforms. [provided by RefSeq, Jan 2016]

Canonical amino-acid sequenceUniProt

502 residues, UniProt reviewed canonical sequence.

>Q6UW63|POGLUT2
     1  MFGTLLLYCF FLATVPALAE TGGERQLSPE KSEIWGPGLK ADVVLPARYF YIQAVDTSGN
    61  KFTSSPGEKV FQVKVSAPEE QFTRVGVQVL DRKDGSFIVR YRMYASYKNL KVEIKFQGQH
   121  VAKSPYILKG PVYHENCDCP LQDSAAWLRE MNCPETIAQI QRDLAHFPAV DPEKIAVEIP
   181  KRFGQRQSLC HYTLKDNKVY IKTHGEHVGF RIFMDAILLS LTRKVKMPDV ELFVNLGDWP
   241  LEKKKSNSNI HPIFSWCGST DSKDIVMPTY DLTDSVLETM GRVSLDMMSV QANTGPPWES
   301  KNSTAVWRGR DSRKERLELV KLSRKHPELI DAAFTNFFFF KHDENLYGPI VKHISFFDFF
   361  KHKYQINIDG TVAAYRLPYL LVGDSVVLKQ DSIYYEHFYN ELQPWKHYIP VKSNLSDLLE
   421  KLKWAKDHDE EAKKIAKAGQ EFARNNLMGD DIFCYYFKLF QEYANLQVSE PQIREGMKRV
   481  EPQTEDDLFP CTCHRKKTKD EL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against POGLUT2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 12 nTPM

Expression across tissuesHPA

Tissue

ovary: 12 nTPM
smooth muscle: 11 nTPM
placenta: 11 nTPM
endometrium: 9.4 nTPM
gallbladder: 7.5 nTPM
liver: 7 nTPM

Single-cell type

extravillous trophoblasts: 32 nCPM
hepatic stellate cells: 19 nCPM
decidual stromal cells: 19 nCPM
peritubular myoid cells: 11 nCPM
oligodendrocyte progenitor cells: 10 nCPM
migrating cytotrophoblasts: 9.2 nCPM

Immune cell

NK-cell: 3.4 nTPM
MAIT T-cell: 2.2 nTPM
gdT-cell: 1.2 nTPM
memory CD8 T-cell: 0.8 nTPM
T-reg: 0.8 nTPM
memory CD4 T-cell: 0.6 nTPM

Brain region

white matter: 1.9 nTPM
basal ganglia: 1.8 nTPM
cerebellum: 1.5 nTPM
choroid plexus: 1.5 nTPM
medulla oblongata: 1.4 nTPM
pons: 1.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.99
gnomAD pLI: 0
DepMap mean gene effect: -0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

protein O-linked glycosylation via glucose

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads POGLUT2 as an antibody target. Whether an autoantibody or antibody against POGLUT2 could matter depends on whether native POGLUT2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

POGLUT2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label POGLUT2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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