Seroatlas · Human Serome Atlas

PNOC

Prepronociceptin

Also known as: N/OFQ, NOP, PNOC_HUMAN, PPNOC

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q13519
Gene: PNOC
Ensembl: ENSG00000168081
Chromosome: 8
Canonical length: 176 aa
Protein class: Predicted intracellular proteins, Predicted secreted proteins, Transporters
Subcellular location: Vesicles
Secretome location: Secreted to blood

OverviewNCBI Gene

This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include nociceptin, nocistatin, and orphanin FQ2 (OFQ2). Nociceptin, also known as orphanin FQ, is a 17-amino acid neuropeptide that binds to the nociceptin receptor to induce increased pain sensitivity, and may additionally regulate body temperature, learning and memory, and hunger. Another product of the encoded preproprotein, nocistatin, may inhibit the effects of nociceptin. [provided by RefSeq, Jul 2015]

Canonical amino-acid sequenceUniProt

176 residues, UniProt reviewed canonical sequence.

>Q13519|PNOC
     1  MKVLLCDLLL LSLFSSVFSS CQRDCLTCQE KLHPALDSFD LEVCILECEE KVFPSPLWTP
    61  CTKVMARSSW QLSPAAPEHV AAALYQPRAS EMQHLRRMPR VRSLFQEQEE PEPGMEEAGE
   121  MEQKQLQKRF GGFTGARKSA RKLANQKRFS EFMRQYLVLS MQSSQRRRTL HQNGNV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PNOC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.57
Highest tissue expression: 28 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 28 nTPM
lymph node: 23 nTPM
tonsil: 22 nTPM
fallopian tube: 17 nTPM
spleen: 14 nTPM
appendix: 9.3 nTPM

Single-cell type

plasma cells: 100 nCPM
b-cells: 43 nCPM
fallopian secretory cells: 43 nCPM
pdcs: 35 nCPM
brain inhibitory neurons: 20 nCPM
other brain neurons: 16 nCPM

Immune cell

naive B-cell: 262 nTPM
memory B-cell: 232 nTPM
plasmacytoid DC: 195 nTPM
classical monocyte: 12 nTPM
total PBMC: 11 nTPM
intermediate monocyte: 7.7 nTPM

Brain region

spinal cord: 30 nTPM
medulla oblongata: 21 nTPM
cerebral cortex: 20 nTPM
pons: 19 nTPM
hypothalamus: 19 nTPM
midbrain: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.1
gnomAD pLI: 0.02
gnomAD missense Z: 0.64
DepMap mean gene effect: 0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PNOC as an antibody target. Whether an autoantibody or antibody against PNOC could matter depends on whether native PNOC is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PNOC is annotated as secreted, so native PNOC circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label PNOC as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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