Seroatlas · Human Serome Atlas

PNMA8C

Paraneoplastic antigen-like protein 8C

Also known as: PNM8C_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A1B0GUJ8
Gene
PNMA8C
Ensembl
ENSG00000277531
Chromosome
19
Canonical length
204 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for PNMA8C in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

204 residues, UniProt reviewed canonical sequence.

>A0A1B0GUJ8|PNMA8C
     1  MLFGVKDIAL LEHGCKALEV DSYKSLMILG IPEDCNHEEF EEIIRLPLKP LGKFEVAGKA
    61  YLEEDKSKAA IIQLTEDINY AVVPREIKGK GGVWRVVYMP RKQDIEFLTK LNLFLQSEGR
   121  TVEDMARVLR QELCPPATGP RELPARKCSV PGLGEKPEAG ATVQMDVVPP LDSSEKESKA
   181  GVGKRGKRKN KKNRRRHHAS DKKL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PNMA8C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.48
Highest tissue expression
18 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 18 nTPM
  • hypothalamus: 17 nTPM
  • hippocampal formation: 10 nTPM
  • basal ganglia: 9.3 nTPM
  • amygdala: 8.7 nTPM
  • pituitary gland: 8.1 nTPM

Single-cell type

  • ependymal cells: 55 nCPM
  • other brain neurons: 24 nCPM
  • brain excitatory neurons: 13 nCPM
  • brain inhibitory neurons: 12 nCPM
  • epididymal principal cells: 10 nCPM
  • gonadotrophs: 9.7 nCPM

Immune cell

  • basophil: 0.6 nTPM
  • neutrophil: 0.4 nTPM
  • NK-cell: 0.3 nTPM
  • naive B-cell: 0.1 nTPM
  • plasmacytoid DC: 0.1 nTPM
  • classical monocyte: 0 nTPM

Brain region

  • hypothalamus: 42 nTPM
  • basal ganglia: 36 nTPM
  • cerebral cortex: 33 nTPM
  • midbrain: 32 nTPM
  • thalamus: 29 nTPM
  • hippocampal formation: 28 nTPM

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PNMA8C as an antibody target. Whether an autoantibody or antibody against PNMA8C could matter depends on whether native PNMA8C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PNMA8C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PNMA8C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PNMA8C. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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