Seroatlas · Human Serome Atlas

PNMA8B

Paraneoplastic antigen-like protein 8B

Also known as: KIAA1183, PNM8B_HUMAN, PNMAL2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9ULN7
Gene: PNMA8B
Ensembl: ENSG00000204851
Chromosome: 19
Canonical length: 635 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for PNMA8B in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

635 residues, UniProt reviewed canonical sequence.

>Q9ULN7|PNMA8B
     1  MAMSLLQDWC RSLDVDAHRA LLVTGIPEGL EQADVEAVLQ PTLLPLGTFR LRHMKALMNE
    61  KAQAALVEFV EDVNHAAIPR EIPGKDGVWR VLWKDRAQDT RVLRQMRRLL LDDGPTQAAE
   121  AGTPGEAPTP PASETQAQDS GEVTGQAGSL LGAARNPRRG RRGRRNRTRR NRLTQKGKKR
   181  SRGGRPSAPA RSEAEDSSDE SLGIVIEEID QGDLSGEEDQ SALYATLQAA ARELVRQWAP
   241  CNSEGEEDGP REFLALVTVT DKSKKEEAEK EPAGAESIRL NTKEDKNGVP DLVALLAVRD
   301  TPDEEPVDSD TSESDSQESG DQETEELDNP EFVAIVAYTD PSDPWAREEM LKIASVIESL
   361  GWSDEKDKRD PLRQVLSVMS KDTNGTRVKV EEAGREVDAV VLRKAGDDGD LRECISTLAQ
   421  PDLPPQAKKA GRGLFGGWSE HREDEGGLLE LVALLAAQDM AEVMKEEKEN AWEGGKYKYP
   481  KGKLGEVLAL LAARENMGSN EGSEEASDEQ SEEESEDTES EASEPEDRAS RKPRAKRART
   541  APRGLTPAGA PPTASGARKT RAGGRGRGRG VTPEKKAGSR GSAQDDAAGS RKKKGSAGAG
   601  AHARAGEAKG QAPTGSKAAR GKKARRGRRL PPKCR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PNMA8B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 55 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 55 nTPM
hypothalamus: 46 nTPM
amygdala: 29 nTPM
hippocampal formation: 28 nTPM
basal ganglia: 21 nTPM
midbrain: 18 nTPM

Single-cell type

retinal amacrine cells: 0.7 nCPM
other brain neurons: 0.3 nCPM
brain excitatory neurons: 0.1 nCPM
brain inhibitory neurons: 0.1 nCPM
gonadotrophs: 0.1 nCPM
lymphatic endothelial cells: 0.1 nCPM

Immune cell

naive CD4 T-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

cerebral cortex: 138 nTPM
basal ganglia: 121 nTPM
pons: 112 nTPM
hypothalamus: 107 nTPM
white matter: 90 nTPM
medulla oblongata: 86 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0
gnomAD pLI: 0
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PNMA8B as an antibody target. Whether an autoantibody or antibody against PNMA8B could matter depends on whether native PNMA8B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PNMA8B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PNMA8B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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