Seroatlas · Human Serome Atlas

PNMA8A

Paraneoplastic antigen-like protein 8A

Also known as: FLJ10781, KIAA1183L, PNM8A_HUMAN, PNMAL1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86V59
Gene: PNMA8A
Ensembl: ENSG00000182013
Chromosome: 19
Canonical length: 439 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear bodies,Cytosol

OverviewNCBI Gene

No narrative summary is available for PNMA8A in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

439 residues, UniProt reviewed canonical sequence.

>Q86V59|PNMA8A
     1  MSKTMAMNLL EDWCRGMEVD IHRSLLVTGI PEDCGQAEIE ETLNGVLSPL GPYRVLNKIF
    61  VREENVKAAL IEVGEGVNLS TIPREFPGRG GVWRVVCRDP TQDAEFLKNL NEFLDAEGRT
   121  WEDVVRLLQL NHPTLSQNQH QPPENWAEAL GVLLGAVVQI IFCMDAEIRS REEARAQEAA
   181  EFEEMAAWAL AAGRKVKKEP GLAAEVGSAL KAETPNNWNA TEDQHEPTKP LVRRAGAKSR
   241  SRRKKQKKNS RQEAVPWKKP KGINSNSTAN LEDPEVGDAE SMAISEPIKG SRKPCVNKEE
   301  LALKKPMAKC AWKGPREPPQ DARAEAESPG GASESDQDGG HESPPKKKAV AWVSAKNPAP
   361  MRKKKKVSLG PVSYVLVDSE DGRKKPVMPK KGPGSRREAS DQKAPRGQQP AEATASTSRG
   421  PKAKPEGSPR RATNESRKV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PNMA8A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 76 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 76 nTPM
hypothalamus: 66 nTPM
cerebellum: 55 nTPM
basal ganglia: 53 nTPM
amygdala: 41 nTPM
hippocampal formation: 36 nTPM

Single-cell type

other brain neurons: 44 nCPM
corticotrophs: 43 nCPM
brain inhibitory neurons: 35 nCPM
differentiating spermatogonia: 34 nCPM
retinal pigment epithelial cells: 34 nCPM
late primary spermatocytes: 32 nCPM

Immune cell

basophil: 0.6 nTPM
naive CD8 T-cell: 0.6 nTPM
memory B-cell: 0.2 nTPM
memory CD8 T-cell: 0.2 nTPM
neutrophil: 0.1 nTPM
NK-cell: 0.1 nTPM

Brain region

hypothalamus: 133 nTPM
cerebral cortex: 130 nTPM
basal ganglia: 113 nTPM
pons: 94 nTPM
white matter: 89 nTPM
thalamus: 84 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.92
gnomAD pLI: 0
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Paraneoplastic antigen Ma
Paraneoplastic antigen Ma-like, N-terminal domain
PNMA N-terminal RRM-like domain
Paraneoplastic antigen-like protein 8A, C-terminal
Paraneoplastic antigen 8A protein

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PNMA8A as an antibody target. Whether an autoantibody or antibody against PNMA8A could matter depends on whether native PNMA8A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PNMA8A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PNMA8A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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