Seroatlas · Human Serome Atlas

PNCK

Calcium/calmodulin-dependent protein kinase type 1B

Also known as: CaMK1b, KCC1B_HUMAN, MGC45419

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6P2M8
Gene: PNCK
Ensembl: ENSG00000130822
Chromosome: X
Canonical length: 343 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Golgi apparatus,Plasma membrane,Cytosol

OverviewNCBI Gene

PNCK is a member of the calcium/calmodulin-dependent protein kinase family of protein serine/threonine kinases (see CAMK1; MIM 604998) (Gardner et al., 2000 [PubMed 10673339]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

343 residues, UniProt reviewed canonical sequence.

>Q6P2M8|PNCK
     1  MLLLKKHTED ISSVYEIRER LGSGAFSEVV LAQERGSAHL VALKCIPKKA LRGKEALVEN
    61  EIAVLRRISH PNIVALEDVH ESPSHLYLAM ELVTGGELFD RIMERGSYTE KDASHLVGQV
   121  LGAVSYLHSL GIVHRDLKPE NLLYATPFED SKIMVSDFGL SKIQAGNMLG TACGTPGYVA
   181  PELLEQKPYG KAVDVWALGV ISYILLCGYP PFYDESDPEL FSQILRASYE FDSPFWDDIS
   241  ESAKDFIRHL LERDPQKRFT CQQALRHLWI SGDTAFDRDI LGSVSEQIRK NFARTHWKRA
   301  FNATSFLRHI RKLGQIPEGE GASEQGMARH SHSGLRAGQP PKW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PNCK can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 101 nTPM

Expression across tissuesHPA

Tissue

basal ganglia: 101 nTPM
colon: 78 nTPM
cerebral cortex: 74 nTPM
amygdala: 64 nTPM
hippocampal formation: 59 nTPM
hypothalamus: 50 nTPM

Single-cell type

extravillous trophoblasts: 94 nCPM
smooth muscle cells: 90 nCPM
syncytiotrophoblasts: 79 nCPM
migrating cytotrophoblasts: 76 nCPM
other brain neurons: 62 nCPM
cone photoreceptor cells: 60 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hypothalamus: 138 nTPM
cerebral cortex: 111 nTPM
hippocampal formation: 102 nTPM
basal ganglia: 100 nTPM
amygdala: 84 nTPM
white matter: 64 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.1
gnomAD pLI: 0
gnomAD missense Z: 1.51
DepMap mean gene effect: 0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

signal transduction

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Protein kinase domain
Serine/threonine-protein kinase, active site
Protein kinase-like domain superfamily
Protein kinase, ATP binding site
Protein kinase domain
Calcium/calmodulin-dependent protein kinase type 1B, catalytic domain

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PNCK as an antibody target. Whether an autoantibody or antibody against PNCK could matter depends on whether native PNCK is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PNCK is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PNCK as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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