Seroatlas · Human Serome Atlas

PMS2CL

Protein PMS2CL

Also known as: PMS2L_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q68D20
Gene: PMS2CL
Canonical length: 193 aa

OverviewNCBI Gene

No narrative summary is available for PMS2CL in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

193 residues, UniProt reviewed canonical sequence.

>Q68D20|PMS2CL
     1  MHAADLEKPM VEKQDQSPSL RTGEEKRDVS ISRLREAFSL RHTTENKPHS PKTPEPRRSP
    61  LGQKRGMSSS STSDAISDRG VLRPQKEAVS SSQGPSDPTD RAEVEKDSGH GSTSVDSEGF
   121  SIPDTGSHCS SECVASTPGD RGSQEHVDSQ EKAPETDDSF SDVDCHSNQE DTGCKFQVLP
   181  QPTNLTSPNT KVF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PMS2CL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.71

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 13% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PMS2CL as an antibody target. Whether an autoantibody or antibody against PMS2CL could matter depends on whether native PMS2CL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PMS2CL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PMS2CL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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