Seroatlas · Human Serome Atlas

PMCH

Pro-MCH

Also known as: MCH, MCH_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P20382
Gene: PMCH
Ensembl: ENSG00000183395
Chromosome: 12
Canonical length: 165 aa
Protein class: Predicted secreted proteins
Secretome location: Secreted to blood

OverviewNCBI Gene

This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include melanin-concentrating hormone (MCH), neuropeptide-glutamic acid-isoleucine (NEI), and neuropeptide-glycine-glutamic acid (NGE). Melanin-concentrating hormone is a 19-amino acid neuropeptide that stimulates hunger and may additionally regulate energy homeostasis, reproductive function, and sleep. Pseudogenes of this gene have been identified on chromosome 5. [provided by RefSeq, Jul 2015]

Canonical amino-acid sequenceUniProt

165 residues, UniProt reviewed canonical sequence.

>P20382|PMCH
     1  MAKMNLSSYI LILTFSLFSQ GILLSASKSI RNLDDDMVFN TFRLGKGFQK EDTAEKSVIA
    61  PSLEQYKNDE SSFMNEEENK VSKNTGSKHN FLNHGLPLNL AIKPYLALKG SVAFPAENGV
   121  QNTESTQEKR EIGDEENSAK FPIGRRDFDM LRCMLGRVYR PCWQV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PMCH can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.65
Highest tissue expression: 713 nTPM

Expression across tissuesHPA

Tissue

hypothalamus: 713 nTPM
midbrain: 3.3 nTPM
lymph node: 0.9 nTPM
thymus: 0.9 nTPM
amygdala: 0.8 nTPM
bone marrow: 0.6 nTPM

Single-cell type

other brain neurons: 81 nCPM
t-cells: 4.9 nCPM
respiratory ionocytes: 2.5 nCPM
epicardial cells: 2.3 nCPM
brain excitatory neurons: 1.9 nCPM
oligodendrocytes: 1.4 nCPM

Immune cell

T-reg: 9.6 nTPM
memory CD4 T-cell: 1 nTPM
NK-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM

Brain region

hypothalamus: 203 nTPM
thalamus: 128 nTPM
midbrain: 48 nTPM
basal ganglia: 6.2 nTPM
cerebral cortex: 1.3 nTPM
pons: 0.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.2
gnomAD pLI: 0.11
gnomAD missense Z: 0.27
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PMCH as an antibody target. Whether an autoantibody or antibody against PMCH could matter depends on whether native PMCH is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PMCH is annotated as secreted, so native PMCH circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label PMCH as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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