Seroatlas · Human Serome Atlas

PLXDC1

Plexin domain-containing protein 1

Also known as: PLDX1_HUMAN, TEM3, TEM7

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IUK5
Gene: PLXDC1
Ensembl: ENSG00000161381
Chromosome: 17
Canonical length: 500 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Secretome location: Intracellular and membrane

OverviewNCBI Gene

Predicted to be involved in angiogenesis. Part of receptor complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

500 residues, UniProt reviewed canonical sequence.

>Q8IUK5|PLXDC1
     1  MRGELWLLVL VLREAARALS PQPGAGHDEG PGSGWAAKGT VRGWNRRARE SPGHVSEPDR
    61  TQLSQDLGGG TLAMDTLPDN RTRVVEDNHS YYVSRLYGPS EPHSRELWVD VAEANRSQVK
   121  IHTILSNTHR QASRVVLSFD FPFYGHPLRQ ITIATGGFIF MGDVIHRMLT ATQYVAPLMA
   181  NFNPGYSDNS TVVYFDNGTV FVVQWDHVYL QGWEDKGSFT FQAALHHDGR IVFAYKEIPM
   241  SVPEISSSQH PVKTGLSDAF MILNPSPDVP ESRRRSIFEY HRIELDPSKV TSMSAVEFTP
   301  LPTCLQHRSC DACMSSDLTF NCSWCHVLQR CSSGFDRYRQ EWMDYGCAQE AEGRMCEDFQ
   361  DEDHDSASPD TSFSPYDGDL TTTSSSLFID SLTTEDDTKL NPYAGGDGLQ NNLSPKTKGT
   421  PVHLGTIVGI VLAVLLVAAI ILAGIYINGH PTSNAALFFI ERRPHHWPAM KFRSHPDHST
   481  YAEVEPSGHE KEGFMEAEQC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PLXDC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 45 nTPM

Expression across tissuesHPA

Tissue

retina: 45 nTPM
heart muscle: 22 nTPM
thymus: 22 nTPM
tongue: 17 nTPM
ovary: 14 nTPM
gallbladder: 13 nTPM

Single-cell type

retinal bipolar cells: 489 nCPM
fibro-adipogenic progenitors: 105 nCPM
retinal amacrine cells: 97 nCPM
retinal ganglion cells: 85 nCPM
pericytes: 84 nCPM
myosatellite cells: 51 nCPM

Immune cell

naive CD8 T-cell: 2.3 nTPM
naive CD4 T-cell: 2.1 nTPM
gdT-cell: 1.8 nTPM
MAIT T-cell: 1.5 nTPM
NK-cell: 1.1 nTPM
plasmacytoid DC: 0.9 nTPM

Brain region

cerebral cortex: 20 nTPM
midbrain: 18 nTPM
cerebellum: 17 nTPM
thalamus: 14 nTPM
pons: 13 nTPM
white matter: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.91
gnomAD pLI: 0
gnomAD missense Z: 1.02
DepMap mean gene effect: -0.15
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PLXDC1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

NID1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PLXDC1 as an antibody target. Whether an autoantibody or antibody against PLXDC1 could matter depends on whether native PLXDC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PLXDC1 is annotated at the cell surface, where native PLXDC1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PLXDC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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