Seroatlas · Human Serome Atlas

PLSCR5

Phospholipid scramblase family member 5

Also known as: PLS5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A0PG75
Gene: PLSCR5
Ensembl: ENSG00000231213
Chromosome: 3
Canonical length: 271 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Predicted to enable phospholipid scramblase activity. Predicted to be involved in plasma membrane phospholipid scrambling. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

271 residues, UniProt reviewed canonical sequence.

>A0PG75|PLSCR5
     1  MASKDAQNQR RGLPGFLPGA PDPDQSLPAS SNPGNQAWQL SLPLPSSFLP TVSLPPGLEY
    61  LSQLDLIIIH QQVELLGMIL GTETSNKYEI KNSLGQRIYF AVEESICFNR TFCSTLRSCT
   121  LRITDNSGRE VITVNRPLRC NSCWCPCYLQ ELEIQAPPGT IVGYVTQKWD PFLPKFTIQN
   181  ANKEDILKIV GPCVTCGCFG DVDFEVKTIN EKLTIGKISK YWSGFVNDVF TNADNFGIHV
   241  PADLDVTVKA AMIGACFLFD FMFFEHSLAG L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PLSCR5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 0.4 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 0.4 nTPM
basal ganglia: 0.2 nTPM
pituitary gland: 0.2 nTPM
amygdala: 0.1 nTPM
cerebral cortex: 0.1 nTPM
colon: 0.1 nTPM

Single-cell type

gonadotrophs: 2.7 nCPM
cone photoreceptor cells: 2.1 nCPM
brain inhibitory neurons: 1.8 nCPM
foveolar cells: 1.5 nCPM
late primary spermatocytes: 1 nCPM
brain excitatory neurons: 0.5 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hypothalamus: 2.1 nTPM
midbrain: 2.1 nTPM
medulla oblongata: 0.8 nTPM
pons: 0.6 nTPM
basal ganglia: 0.5 nTPM
cerebral cortex: 0.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.67
gnomAD pLI: 0
gnomAD missense Z: -1.17
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PLSCR5 as an antibody target. Whether an autoantibody or antibody against PLSCR5 could matter depends on whether native PLSCR5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PLSCR5 is annotated at the cell surface, where native PLSCR5 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PLSCR5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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