Seroatlas · Human Serome Atlas

PLSCR4

Phospholipid scramblase 4

Also known as: PLS4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NRQ2
Gene
PLSCR4
Ensembl
ENSG00000114698
Chromosome
3
Canonical length
329 aa
Protein class
Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location
Nucleoplasm,Nuclear bodies

OverviewNCBI Gene

Enables CD4 receptor binding activity; enzyme binding activity; and phospholipid scramblase activity. Involved in calcium activated phosphatidylcholine scrambling and calcium activated phosphatidylserine scrambling. Located in nucleus and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

329 residues, UniProt reviewed canonical sequence.

>Q9NRQ2|PLSCR4
     1  MSGVVPTAPE QPAGEMENQT KPPDPRPDAP PEYNSHFLPG PPGTAVPPPT GYPGGLPMGY
    61  YSPQQPSTFP LYQPVGGIHP VRYQPGKYPM PNQSVPITWM PGPTPMANCP PGLEYLVQLD
   121  NIHVLQHFEP LEMMTCFETN NRYDIKNNSD QMVYIVTEDT DDFTRNAYRT LRPFVLRVTD
   181  CMGREIMTMQ RPFRCTCCCF CCPSARQELE VQCPPGVTIG FVAEHWNLCR AVYSIQNEKK
   241  ENVMRVRGPC STYGCGSDSV FEVKSLDGIS NIGSIIRKWN GLLSAMADAD HFDIHFPLDL
   301  DVKMKAMIFG ACFLIDFMYF ERSPPQRSR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PLSCR4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.4
Highest tissue expression
66 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 66 nTPM
  • liver: 65 nTPM
  • adipose tissue: 57 nTPM
  • placenta: 53 nTPM
  • gallbladder: 43 nTPM
  • adrenal gland: 41 nTPM

Single-cell type

  • lymphatic endothelial cells: 462 nCPM
  • bergmann glia: 306 nCPM
  • fibro-adipogenic progenitors: 303 nCPM
  • sertoli cells: 267 nCPM
  • vascular endothelial cells: 220 nCPM
  • mesothelial cells: 202 nCPM

Immune cell

  • NK-cell: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • midbrain: 91 nTPM
  • thalamus: 87 nTPM
  • medulla oblongata: 80 nTPM
  • hypothalamus: 79 nTPM
  • spinal cord: 75 nTPM
  • white matter: 63 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PLSCR4.

Disease | ImmuneIEDB

Conditions an epitope on PLSCR4 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.15
gnomAD pLI
0
gnomAD missense Z
0.43
DepMap mean gene effect
0.18
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PLSCR4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PLSCR4 as an antibody target. Whether an autoantibody or antibody against PLSCR4 could matter depends on whether native PLSCR4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PLSCR4 is annotated at the cell surface, where native PLSCR4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PLSCR4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PLSCR4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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