Seroatlas · Human Serome Atlas

PLSCR2

Phospholipid scramblase 2

Also known as: PLS2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NRY7
Gene: PLSCR2
Ensembl: ENSG00000163746
Chromosome: 3
Canonical length: 297 aa
Protein class: Predicted intracellular proteins, Transporters
Subcellular location: Nucleoplasm,Endoplasmic reticulum,Vesicles

OverviewNCBI Gene

This gene encodes a member of the phospholipid scramblase family. Phospholipid scramblases are membrane proteins that mediate calcium-dependent, non-specific movement of plasma membrane phospholipids and phosphatidylserine exposure. The encoded protein contains a low affinity calcium binding motif and may play a role in blood coagulation and apoptosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

Canonical amino-acid sequenceUniProt

297 residues, UniProt reviewed canonical sequence.

>Q9NRY7|PLSCR2
     1  MRSWNSLFCL NSSRPPGHIV YPKHQAGHTG KQADHLGSQA FYPGRQHDYL VPPAGTAGIP
    61  VQNQPGRPEG VPWMPAPPPP LNCPPGLEYL SQIDMILIHQ QIELLEVLFS FESSNMYEIK
   121  NSFGQRIYFA AEDTNFCIRN CCGRSRPFTL RITDNVGREV ITLERPLRCN CCCCPCCLQE
   181  IEIQAPPGVP VGYVTQTWHP CLTKFTIKNQ KREDVLKISG PCIVCSCIAG VDFEITSLDE
   241  QIVVGRISKH WSGFLREAFT DADNFGIQFP RDLDVKMKAV MIGACFLIDY MFFERTR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PLSCR2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

testis: 13 nTPM
epididymis: 1.4 nTPM
bone marrow: 1.1 nTPM
fallopian tube: 0.5 nTPM
gallbladder: 0.5 nTPM
pancreas: 0.5 nTPM

Single-cell type

late spermatids: 438 nCPM
early spermatids: 300 nCPM
late primary spermatocytes: 121 nCPM
renal collecting duct principal cells: 43 nCPM
renal connecting tubule cells: 39 nCPM
distal convoluted tubule cells: 34 nCPM

Immune cell

classical monocyte: 0.2 nTPM
memory CD8 T-cell: 0.2 nTPM
naive CD4 T-cell: 0.2 nTPM
naive CD8 T-cell: 0.2 nTPM
neutrophil: 0.2 nTPM
NK-cell: 0.2 nTPM

Brain region

medulla oblongata: 2.5 nTPM
cerebral cortex: 2.2 nTPM
hypothalamus: 2.2 nTPM
pons: 2.1 nTPM
thalamus: 2.1 nTPM
spinal cord: 2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.22
gnomAD pLI: 0
gnomAD missense Z: 0.88
DepMap mean gene effect: -0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

plasma membrane phospholipid scrambling

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PLSCR2 as an antibody target. Whether an autoantibody or antibody against PLSCR2 could matter depends on whether native PLSCR2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PLSCR2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PLSCR2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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