Seroatlas · Human Serome Atlas

PLPPR4

Phospholipid phosphatase-related protein type 4

Also known as: KIAA0455, LPPR4, PHP1, PLPR4_HUMAN, PRG-1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q7Z2D5
Gene
PLPPR4
Ensembl
ENSG00000117600
Chromosome
1
Canonical length
763 aa
Protein class
Metabolic proteins, Predicted membrane proteins

OverviewNCBI Gene

The protein encoded by this gene belongs to the lipid phosphate phosphatase (LPP) family. LPPs catalyze the dephosphorylation of a number of bioactive lipid mediators that regulate a variety of cell functions. This protein is specifically expressed in neurons. It is located in the membranes of outgrowing axons and has been shown to be important for axonal outgrowth during development and regenerative sprouting. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]

Canonical amino-acid sequenceUniProt

763 residues, UniProt reviewed canonical sequence.

>Q7Z2D5|PLPPR4
     1  MQRAGSSGGR GECDISGAGR LGLEEAARLS CAVHTSPGGG RRPGQAAGMS AKERPKGKVI
    61  KDSVTLLPCF YFVELPILAS SVVSLYFLEL TDVFKPVHSG FSCYDRSLSM PYIEPTQEAI
   121  PFLMLLSLAF AGPAITIMVG EGILYCCLSK RRNGVGLEPN INAGGCNFNS FLRRAVRFVG
   181  VHVFGLCSTA LITDIIQLST GYQAPYFLTV CKPNYTSLNV SCKENSYIVE DICSGSDLTV
   241  INSGRKSFPS QHATLAAFAA VYVSMYFNST LTDSSKLLKP LLVFTFIICG IICGLTRITQ
   301  YKNHPVDVYC GFLIGGGIAL YLGLYAVGNF LPSDESMFQH RDALRSLTDL NQDPNRLLSA
   361  KNGSSSDGIA HTEGILNRNH RDASSLTNLK RANADVEIIT PRSPMGKENM VTFSNTLPRA
   421  NTPSVEDPVR RNASIHASMD SARSKQLLTQ WKNKNESRKL SLQVIEPEPG QSPPRSIEMR
   481  SSSEPSRVGV NGDHHGPGNQ YLKIQPGAVP GCNNSMPGGP RVSIQSRPGS SQLVHIPEET
   541  QENISTSPKS SSARAKWLKA AEKTVACNRS NSQPRIMQVI AMSKQQGVLQ SSPKNTEGST
   601  VSCTGSIRYK TLTDHEPSGI VRVEAHPENN RPIIQIPSTE GEGSGSWKWK APEKGSLRQT
   661  YELNDLNRDS ESCESLKDSF GSGDRKRSNI DSNEHHHHGI TTIRVTPVEG SEIGSETLSI
   721  SSSRDSTLRR KGNIILIPER SNSPENTRNI FYKGTSPTRA YKD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PLPPR4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
6
Mean surface accessibility (rSASA)
0.56
Highest tissue expression
50 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 50 nTPM
  • basal ganglia: 9.5 nTPM
  • retina: 6.6 nTPM
  • urinary bladder: 6.3 nTPM
  • hippocampal formation: 5.1 nTPM
  • hypothalamus: 5.1 nTPM

Single-cell type

  • brain inhibitory neurons: 199 nCPM
  • thyrotrophs: 198 nCPM
  • lactotrophs: 188 nCPM
  • melanocytes: 182 nCPM
  • brain excitatory neurons: 176 nCPM
  • other brain neurons: 154 nCPM

Immune cell

  • non-classical monocyte: 0.3 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • hippocampal formation: 109 nTPM
  • cerebral cortex: 94 nTPM
  • basal ganglia: 71 nTPM
  • amygdala: 59 nTPM
  • hypothalamus: 42 nTPM
  • white matter: 35 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.37
gnomAD pLI
0.86
DepMap mean gene effect
-0.1
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PLPPR4 as an antibody target. Whether an autoantibody or antibody against PLPPR4 could matter depends on whether native PLPPR4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PLPPR4 is annotated at the cell surface, where native PLPPR4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PLPPR4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PLPPR4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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