Seroatlas · Human Serome Atlas

PLPPR3

Phospholipid phosphatase-related protein type 3

Also known as: FLJ11535, LPPR3, PLPR3_HUMAN, PRG-2, PRG2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6T4P5
Gene
PLPPR3
Ensembl
ENSG00000129951
Chromosome
19
Canonical length
718 aa
Protein class
Metabolic proteins, Predicted membrane proteins
Subcellular location
Nucleoplasm,Golgi apparatus,Cytosol

OverviewNCBI Gene

The proteins in the lipid phosphate phosphatase (LPP) family, including PRG2, are integral membrane proteins that modulate bioactive lipid phosphates including phosphatidate, lysophosphatidate, and sphingosine-1-phosphate in the context of cell migration, neurite retraction, and mitogenesis (Brauer et al., 2003 [PubMed 12730698]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

718 residues, UniProt reviewed canonical sequence.

>Q6T4P5|PLPPR3
     1  MISTKEKNKI PKDSMTLLPC FYFVELPIVA SSIVSLYFLE LTDLFKPAKV GFQCYDRTLS
    61  MPYVETNEEL IPLLMLLSLA FAAPAASIMV AEGMLYCLQS RLWGRAGGPA GAEGSINAGG
   121  CNFNSFLRRT VRFVGVHVFG LCATALVTDV IQLATGYHTP FFLTVCKPNY TLLGTSCEVN
   181  PYITQDICSG HDIHAILSAR KTFPSQHATL SAFAAVYVSM YFNSVISDTT KLLKPILVFA
   241  FAIAAGVCGL TQITQYRSHP VDVYAGFLIG AGIAAYLACH AVGNFQAPPA EKPAAPAPAK
   301  DALRALTQRG HDSVYQQNKS VSTDELGPPG RLEGAPRPVA REKTSLGSLK RASVDVDLLA
   361  PRSPMAKENM VTFSHTLPRA SAPSLDDPAR RHMTIHVPLD ASRSKQLISE WKQKSLEGRG
   421  LGLPDDASPG HLRAPAEPMA EEEEEEEDEE EEEEEEEEED EGPAPPSLYP TVQARPGLGP
   481  RVILPPRAGP PPLVHIPEEG AQTGAGLSPK SGAGVRAKWL MMAEKSGAAV ANPPRLLQVI
   541  AMSKAPGAPG PKAAETASSS SASSDSSQYR SPSDRDSASI VTIDAHAPHH PVVHLSAGGA
   601  PWEWKAAGGG AKAEADGGYE LGDLARGFRG GAKPPGVSPG SSVSDVDQEE PRFGAVATVN
   661  LATGEGLPPL GAADGALGPG SRESTLRRHA GGLGLAEREA EAEAEGYFRK MQARRFPD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PLPPR3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
6
Mean surface accessibility (rSASA)
0.56
Highest tissue expression
40 nTPM

Expression across tissuesHPA

Tissue

  • basal ganglia: 40 nTPM
  • cerebral cortex: 32 nTPM
  • hippocampal formation: 30 nTPM
  • amygdala: 29 nTPM
  • hypothalamus: 23 nTPM
  • bone marrow: 9.3 nTPM

Single-cell type

  • fallopian tube ciliated cells: 112 nCPM
  • respiratory ciliated cells: 104 nCPM
  • endometrial ciliated cells: 37 nCPM
  • other brain neurons: 33 nCPM
  • monocyte progenitors: 24 nCPM
  • brain inhibitory neurons: 22 nCPM

Immune cell

  • eosinophil: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 66 nTPM
  • amygdala: 57 nTPM
  • hippocampal formation: 53 nTPM
  • basal ganglia: 53 nTPM
  • hypothalamus: 50 nTPM
  • midbrain: 46 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.76
gnomAD pLI
0.01
DepMap mean gene effect
-0.11
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PLPPR3 as an antibody target. Whether an autoantibody or antibody against PLPPR3 could matter depends on whether native PLPPR3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PLPPR3 is annotated at the cell surface, where native PLPPR3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PLPPR3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PLPPR3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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