Seroatlas · Human Serome Atlas

PLPPR2

Phospholipid phosphatase-related protein type 2

Also known as: LPPR2, PLPR2_HUMAN, PRG-4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96GM1
Gene: PLPPR2
Ensembl: ENSG00000105520
Chromosome: 19
Canonical length: 343 aa
Protein class: Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable phosphatidate phosphatase activity. Predicted to be involved in phospholipid dephosphorylation; phospholipid metabolic process; and signal transduction. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

343 residues, UniProt reviewed canonical sequence.

>Q96GM1|PLPPR2
     1  MAGGRPHLKR SFSIIPCFVF VESVLLGIVI LLAYRLEFTD TFPVHTQGFF CYDSTYAKPY
    61  PGPEAASRVP PALVYALVTA GPTLTILLGE LARAFFPAPP SAVPVIGEST IVSGACCRFS
   121  PPVRRLVRFL GVYSFGLFTT TIFANAGQVV TGNPTPHFLS VCRPNYTALG CLPPSPDRPG
   181  PDRFVTDQGA CAGSPSLVAA ARRAFPCKDA ALCAYAVTYT AMYVTLVFRV KGSRLVKPSL
   241  CLALLCPAFL VGVVRVAEYR NHWSDVLAGF LTGAAIATFL VTCVVHNFQS RPPSGRRLSP
   301  WEDLGQAPTM DSPLEKNPRS AGRIRHRHGS PHPSRRTAPA VAT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PLPPR2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 6
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 86 nTPM

Expression across tissuesHPA

Tissue

hippocampal formation: 86 nTPM
amygdala: 61 nTPM
pituitary gland: 51 nTPM
basal ganglia: 47 nTPM
cerebral cortex: 43 nTPM
hypothalamus: 41 nTPM

Single-cell type

neutrophils: 86 nCPM
other brain neurons: 39 nCPM
brain excitatory neurons: 32 nCPM
brain inhibitory neurons: 31 nCPM
oligodendrocyte progenitor cells: 30 nCPM
corticotrophs: 29 nCPM

Immune cell

neutrophil: 72 nTPM
classical monocyte: 18 nTPM
intermediate monocyte: 15 nTPM
non-classical monocyte: 11 nTPM
eosinophil: 9.1 nTPM
myeloid DC: 6.7 nTPM

Brain region

hippocampal formation: 211 nTPM
cerebral cortex: 149 nTPM
amygdala: 147 nTPM
hypothalamus: 138 nTPM
basal ganglia: 110 nTPM
pons: 77 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

DepMap mean gene effect: -0.05
DepMap dependency class: none

OntologyGO

Biological processes

Molecular functions

phosphatidate phosphatase activity

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PLPPR2 as an antibody target. Whether an autoantibody or antibody against PLPPR2 could matter depends on whether native PLPPR2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PLPPR2 is annotated at the cell surface, where native PLPPR2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PLPPR2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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