Seroatlas · Human Serome Atlas

PLPPR1

Phospholipid phosphatase-related protein type 1

Also known as: FLJ20300, LPPR1, MGC26189, PLPR1_HUMAN, PRG-3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8TBJ4
Gene
PLPPR1
Ensembl
ENSG00000148123
Chromosome
9
Canonical length
325 aa
Protein class
Predicted membrane proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

This gene encodes a member of the plasticity-related gene (PRG) family. Members of the PRG family mediate lipid phosphate phosphatase activity in neurons and are known to be involved in neuronal plasticity. The protein encoded by this gene does not perform its function through enzymatic phospholipid degradation. This gene is strongly expressed in brain. It shows dynamic expression regulation during brain development and neuronal excitation. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

325 residues, UniProt reviewed canonical sequence.

>Q8TBJ4|PLPPR1
     1  MAVGNNTQRS YSIIPCFIFV ELVIMAGTVL LAYYFECTDT FQVHIQGFFC QDGDLMKPYP
    61  GTEEESFITP LVLYCVLAAT PTAIIFIGEI SMYFIKSTRE SLIAQEKTIL TGECCYLNPL
   121  LRRIIRFTGV FAFGLFATDI FVNAGQVVTG HLTPYFLTVC KPNYTSADCQ AHHQFINNGN
   181  ICTGDLEVIE KARRSFPSKH AALSIYSALY ATMYITSTIK TKSSRLAKPV LCLGTLCTAF
   241  LTGLNRVSEY RNHCSDVIAG FILGTAVALF LGMCVVHNFK GTQGSPSKPK PEDPRGVPLM
   301  AFPRIESPLE TLSAQNHSAS MTEVT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PLPPR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
6
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
25 nTPM

Expression across tissuesHPA

Tissue

  • basal ganglia: 25 nTPM
  • hippocampal formation: 19 nTPM
  • amygdala: 18 nTPM
  • kidney: 15 nTPM
  • spinal cord: 14 nTPM
  • cerebral cortex: 14 nTPM

Single-cell type

  • oligodendrocyte progenitor cells: 804 nCPM
  • oligodendrocytes: 554 nCPM
  • distal convoluted tubule cells: 345 nCPM
  • brain inhibitory neurons: 291 nCPM
  • proximal tubule cells: 158 nCPM
  • renal collecting duct intercalated cells: 101 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • basal ganglia: 17 nTPM
  • cerebral cortex: 15 nTPM
  • white matter: 14 nTPM
  • hypothalamus: 13 nTPM
  • medulla oblongata: 12 nTPM
  • hippocampal formation: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.5
gnomAD pLI
0.57
DepMap mean gene effect
0.08
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PLPPR1 as an antibody target. Whether an autoantibody or antibody against PLPPR1 could matter depends on whether native PLPPR1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PLPPR1 is annotated at the cell surface, where native PLPPR1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PLPPR1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PLPPR1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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