PLPP5
Phospholipid phosphatase 5
Also known as: DPPL1, HTPAP, PLPP5_HUMAN, PPAPDC1B
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8NEB5
- Gene
- PLPP5
- Ensembl
- ENSG00000147535
- Chromosome
- 8
- Canonical length
- 264 aa
- Protein class
- Enzymes, Metabolic proteins, Predicted membrane proteins
- Subcellular location
- Vesicles
OverviewNCBI Gene
Enables diacylglycerol diphosphate phosphatase activity and phosphatidate phosphatase activity. Involved in phospholipid dephosphorylation. Predicted to be located in cytoplasm and plasma membrane. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
264 residues, UniProt reviewed canonical sequence.
>Q8NEB5|PLPP5
1 MGKAAAAVAF GAEVGVRLAL FAAFLVTELL PPFQRLIQPE EMWLYRNPYV EAEYFPTKPM
61 FVIAFLSPLS LIFLAKFLKK ADTRDSRQAC LAASLALALN GVFTNTIKLI VGRPRPDFFY
121 RCFPDGLAHS DLMCTGDKDV VNEGRKSFPS GHSSFAFAGL AFASFYLAGK LHCFTPQGRG
181 KSWRFCAFLS PLLFAAVIAL SRTCDYKHHW QDVLVGSMIG MTFAYVCYRQ YYPPLTDAEC
241 HKPFQDKLVL STAQKPGDSY CFDILocalizationUniProt · AlphaFold · HPA
Whether an antibody against PLPP5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 6
- Mean surface accessibility (rSASA)
- 0.3
- Highest tissue expression
- 108 nTPM
Expression across tissuesHPA
Tissue
- pancreas: 108 nTPM
- salivary gland: 81 nTPM
- epididymis: 77 nTPM
- choroid plexus: 75 nTPM
- prostate: 70 nTPM
- pituitary gland: 50 nTPM
Single-cell type
- plasma cells: 304 nCPM
- epididymal principal cells: 232 nCPM
- gastric chief cells: 180 nCPM
- prostatic glandular cells: 169 nCPM
- gastric progenitor cells: 155 nCPM
- salivary acinar cells: 132 nCPM
Immune cell
- naive B-cell: 307 nTPM
- memory B-cell: 213 nTPM
- basophil: 81 nTPM
- plasmacytoid DC: 26 nTPM
- eosinophil: 23 nTPM
- MAIT T-cell: 23 nTPM
Brain region
- choroid plexus: 63 nTPM
- cerebellum: 19 nTPM
- hypothalamus: 16 nTPM
- midbrain: 15 nTPM
- cerebral cortex: 14 nTPM
- basal ganglia: 13 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.93
- gnomAD pLI
- 0
- DepMap mean gene effect
- 0.09
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads PLPP5 as an antibody target. Whether an autoantibody or antibody against PLPP5 could matter depends on whether native PLPP5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
PLPP5 is annotated at the cell surface, where native PLPP5 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label PLPP5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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