Seroatlas · Human Serome Atlas

PLPP4

Phospholipid phosphatase 4

Also known as: DPPL2, PLPP4_HUMAN, PPAPDC1, PPAPDC1A

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5VZY2
Gene: PLPP4
Ensembl: ENSG00000203805
Chromosome: 10
Canonical length: 271 aa
Protein class: Enzymes, Metabolic proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Nucleoli,Nucleoli rim

OverviewNCBI Gene

Enables diacylglycerol diphosphate phosphatase activity; identical protein binding activity; and phosphatidate phosphatase activity. Involved in phospholipid dephosphorylation and regulation of calcium ion import. Predicted to be located in plasma membrane. Predicted to be active in membrane. Biomarker of breast cancer. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

271 residues, UniProt reviewed canonical sequence.

>Q5VZY2|PLPP4
     1  MRELAIEIGV RALLFGVFVF TEFLDPFQRV IQPEEIWLYK NPLVQSDNIP TRLMFAISFL
    61  TPLAVICVVK IIRRTDKTEI KEAFLAVSLA LALNGVCTNT IKLIVGRPRP DFFYRCFPDG
   121  VMNSEMHCTG DPDLVSEGRK SFPSIHSSFA FSGLGFTTFY LAGKLHCFTE SGRGKSWRLC
   181  AAILPLYCAM MIALSRMCDY KHHWQDSFVG GVIGLIFAYI CYRQHYPPLA NTACHKPYVS
   241  LRVPASLKKE ERPTADSAPS LPLEGITEGP V

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PLPP4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 6
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 2 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 2 nTPM
hypothalamus: 1.7 nTPM
hippocampal formation: 1.6 nTPM
midbrain: 1.5 nTPM
amygdala: 1.2 nTPM
cerebral cortex: 1.2 nTPM

Single-cell type

oligodendrocyte progenitor cells: 322 nCPM
renal connecting tubule cells: 157 nCPM
renal collecting duct intercalated cells: 119 nCPM
leydig cells: 66 nCPM
erythrocyte progenitors: 63 nCPM
brain excitatory neurons: 60 nCPM

Immune cell

basophil: 0.6 nTPM
neutrophil: 0.2 nTPM
NK-cell: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

pons: 27 nTPM
hypothalamus: 21 nTPM
medulla oblongata: 17 nTPM
cerebellum: 15 nTPM
midbrain: 13 nTPM
hippocampal formation: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.02
gnomAD pLI: 0
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PLPP4 as an antibody target. Whether an autoantibody or antibody against PLPP4 could matter depends on whether native PLPP4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PLPP4 is annotated at the cell surface, where native PLPP4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PLPP4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...