Seroatlas · Human Serome Atlas

PLPP3

Phospholipid phosphatase 3

Also known as: LPP3, PAP-2b, PLPP3_HUMAN, PPAP2B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O14495
Gene
PLPP3
Ensembl
ENSG00000162407
Chromosome
1
Canonical length
311 aa
Protein class
Enzymes, Metabolic proteins, Plasma proteins, Predicted membrane proteins
Subcellular location
Golgi apparatus,Mid piece,Principal piece
Quaternary structure
Homodimer

OverviewNCBI Gene

The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is a membrane glycoprotein localized at the cell plasma membrane. It has been shown to actively hydrolyze extracellular lysophosphatidic acid and short-chain phosphatidic acid. The expression of this gene is found to be enhanced by epidermal growth factor in Hela cells. [provided by RefSeq, Mar 2010]

Canonical amino-acid sequenceUniProt

311 residues, UniProt reviewed canonical sequence.

>O14495|PLPP3
     1  MQNYKYDKAI VPESKNGGSP ALNNNPRRSG SKRVLLICLD LFCLFMAGLP FLIIETSTIK
    61  PYHRGFYCND ESIKYPLKTG ETINDAVLCA VGIVIAILAI ITGEFYRIYY LKKSRSTIQN
   121  PYVAALYKQV GCFLFGCAIS QSFTDIAKVS IGRLRPHFLS VCNPDFSQIN CSEGYIQNYR
   181  CRGDDSKVQE ARKSFFSGHA SFSMYTMLYL VLYLQARFTW RGARLLRPLL QFTLIMMAFY
   241  TGLSRVSDHK HHPSDVLAGF AQGALVACCI VFFVSDLFKT KTTLSLPAPA IRKEILSPVD
   301  IIDRNNHHNM M

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PLPP3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
6
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
307 nTPM

Expression across tissuesHPA

Tissue

  • thyroid gland: 307 nTPM
  • cervix: 277 nTPM
  • placenta: 212 nTPM
  • liver: 170 nTPM
  • adipose tissue: 160 nTPM
  • seminal vesicle: 160 nTPM

Single-cell type

  • leydig cells: 599 nCPM
  • endometrial stromal cells: 325 nCPM
  • bergmann glia: 305 nCPM
  • cardiomyocytes: 301 nCPM
  • fibro-adipogenic progenitors: 292 nCPM
  • fibroblasts: 292 nCPM

Immune cell

  • memory B-cell: 2.4 nTPM
  • naive B-cell: 2.3 nTPM
  • neutrophil: 0.4 nTPM
  • classical monocyte: 0.1 nTPM
  • non-classical monocyte: 0.1 nTPM
  • total PBMC: 0.1 nTPM

Brain region

  • thalamus: 180 nTPM
  • medulla oblongata: 170 nTPM
  • midbrain: 169 nTPM
  • amygdala: 138 nTPM
  • basal ganglia: 136 nTPM
  • hypothalamus: 131 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.38
gnomAD pLI
0.92
DepMap mean gene effect
0.1
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PLPP3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PLPP3 as an antibody target. Whether an autoantibody or antibody against PLPP3 could matter depends on whether native PLPP3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PLPP3 is annotated at the cell surface, where native PLPP3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PLPP3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PLPP3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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