Seroatlas · Human Serome Atlas

PLPP2

Phospholipid phosphatase 2

Also known as: LPP2, PAP-2c, PLPP2_HUMAN, PPAP2C

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O43688
Gene
PLPP2
Ensembl
ENSG00000141934
Chromosome
19
Canonical length
288 aa
Protein class
Enzymes, Metabolic proteins, Predicted membrane proteins
Subcellular location
Plasma membrane
Quaternary structure
Homodimer

OverviewNCBI Gene

The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is similar to phosphatidic acid phosphatase type 2A (PPAP2A) and type 2B (PPAP2B). All three proteins contain 6 transmembrane regions, and a consensus N-glycosylation site. This protein has been shown to possess membrane associated PAP activity. Three alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

288 residues, UniProt reviewed canonical sequence.

>O43688|PLPP2
     1  MQRRWVFVLL DVLCLLVASL PFAILTLVNA PYKRGFYCGD DSIRYPYRPD TITHGLMAGV
    61  TITATVILVS AGEAYLVYTD RLYSRSDFNN YVAAVYKVLG TFLFGAAVSQ SLTDLAKYMI
   121  GRLRPNFLAV CDPDWSRVNC SVYVQLEKVC RGNPADVTEA RLSFYSGHSS FGMYCMVFLA
   181  LYVQARLCWK WARLLRPTVQ FFLVAFALYV GYTRVSDYKH HWSDVLVGLL QGALVAALTV
   241  CYISDFFKAR PPQHCLKEEE LERKPSLSLT LTLGEADHNH YGYPHSSS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PLPP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
6
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
104 nTPM

Expression across tissuesHPA

Tissue

  • salivary gland: 104 nTPM
  • spinal cord: 78 nTPM
  • fallopian tube: 77 nTPM
  • cervix: 60 nTPM
  • duodenum: 59 nTPM
  • skin: 53 nTPM

Single-cell type

  • fallopian tube ciliated cells: 299 nCPM
  • respiratory ciliated cells: 298 nCPM
  • respiratory secretory cells: 249 nCPM
  • breast secretory cells: 227 nCPM
  • submucosal glandular cells: 222 nCPM
  • cholangiocytes: 219 nCPM

Immune cell

  • MAIT T-cell: 6.6 nTPM
  • gdT-cell: 3.3 nTPM
  • memory CD8 T-cell: 1.6 nTPM
  • memory CD4 T-cell: 1.4 nTPM
  • total PBMC: 0.3 nTPM
  • naive CD8 T-cell: 0.1 nTPM

Brain region

  • white matter: 122 nTPM
  • basal ganglia: 78 nTPM
  • medulla oblongata: 71 nTPM
  • cerebellum: 70 nTPM
  • cerebral cortex: 63 nTPM
  • midbrain: 63 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.97
gnomAD pLI
0
DepMap mean gene effect
0
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PLPP2 as an antibody target. Whether an autoantibody or antibody against PLPP2 could matter depends on whether native PLPP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PLPP2 is annotated at the cell surface, where native PLPP2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PLPP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PLPP2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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