Seroatlas · Human Serome Atlas

PLPP1

Phospholipid phosphatase 1

Also known as: LPP1, PAP-2a, PLPP1_HUMAN, PPAP2A

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O14494
Gene: PLPP1
Ensembl: ENSG00000067113
Chromosome: 5
Canonical length: 284 aa
Protein class: Enzymes, Metabolic proteins, Predicted membrane proteins
Subcellular location: Plasma membrane
Quaternary structure: Homodimer

OverviewNCBI Gene

The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in synthesis of glycerolipids and in phospholipase D-mediated signal transduction. This enzyme is an integral membrane glycoprotein that plays a role in the hydrolysis and uptake of lipids from extracellular space. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]

Canonical amino-acid sequenceUniProt

284 residues, UniProt reviewed canonical sequence.

>O14494|PLPP1
     1  MFDKTRLPYV ALDVLCVLLA GLPFAILTSR HTPFQRGVFC NDESIKYPYK EDTIPYALLG
    61  GIIIPFSIIV IILGETLSVY CNLLHSNSFI RNNYIATIYK AIGTFLFGAA ASQSLTDIAK
   121  YSIGRLRPHF LDVCDPDWSK INCSDGYIEY YICRGNAERV KEGRLSFYSG HSSFSMYCML
   181  FVALYLQARM KGDWARLLRP TLQFGLVAVS IYVGLSRVSD YKHHWSDVLT GLIQGALVAI
   241  LVAVYVSDFF KERTSFKERK EEDSHTTLHE TPTTGNHYPS NHQP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PLPP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 6
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 257 nTPM

Expression across tissuesHPA

Tissue

prostate: 257 nTPM
adipose tissue: 169 nTPM
blood vessel: 166 nTPM
gallbladder: 157 nTPM
breast: 142 nTPM
urinary bladder: 123 nTPM

Single-cell type

prostatic glandular cells: 7,829 nCPM
decidual stromal cells: 1,580 nCPM
lymphatic endothelial cells: 1,057 nCPM
vascular endothelial cells: 897 nCPM
schwann cells: 801 nCPM
thymic myoid cells: 696 nCPM

Immune cell

plasmacytoid DC: 15 nTPM
naive CD4 T-cell: 9.5 nTPM
naive CD8 T-cell: 7.7 nTPM
memory B-cell: 6.7 nTPM
memory CD4 T-cell: 5.3 nTPM
eosinophil: 4 nTPM

Brain region

white matter: 85 nTPM
medulla oblongata: 68 nTPM
cerebellum: 67 nTPM
spinal cord: 65 nTPM
choroid plexus: 59 nTPM
pons: 58 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.69
gnomAD pLI: 0.1
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PLPP1 as an antibody target. Whether an autoantibody or antibody against PLPP1 could matter depends on whether native PLPP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PLPP1 is annotated at the cell surface, where native PLPP1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PLPP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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