Seroatlas · Human Serome Atlas

PLP2

Proteolipid protein 2

Also known as: A4, A4-LSB, MGC126187, PLP2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q04941
Gene: PLP2
Ensembl: ENSG00000102007
Chromosome: X
Canonical length: 152 aa
Protein class: Predicted membrane proteins, Transporters

OverviewNCBI Gene

This gene encodes an integral membrane protein that localizes to the endoplasmic reticulum in colonic epithelial cells. The encoded protein can multimerize and may function as an ion channel. A polymorphism in the promoter of this gene may be linked to an increased risk of X-linked cognitive disability. A pseudogene of this gene is found on chromosome 5. [provided by RefSeq, Jan 2010]

Canonical amino-acid sequenceUniProt

152 residues, UniProt reviewed canonical sequence.

>Q04941|PLP2
     1  MADSERLSAP GCWAACTNFS RTRKGILLFA EIILCLVILI CFSASTPGYS SLSVIEMILA
    61  AIFFVVYMCD LHTKIPFINW PWSDFFRTLI AAILYLITSI VVLVERGNHS KIVAGVLGLI
   121  ATCLFGYDAY VTFPVRQPRH TAAPTDPADG PV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PLP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 369 nTPM

Expression across tissuesHPA

Tissue

skin: 369 nTPM
esophagus: 365 nTPM
bone marrow: 339 nTPM
blood vessel: 301 nTPM
vagina: 257 nTPM
pancreas: 246 nTPM

Single-cell type

esophageal suprabasal cells: 1,311 nCPM
esophageal basal cells: 1,131 nCPM
esophageal apical cells: 1,071 nCPM
suprabasal keratinocytes: 504 nCPM
basal keratinocytes: 438 nCPM
pdcs: 398 nCPM

Immune cell

plasmacytoid DC: 696 nTPM
basophil: 489 nTPM
neutrophil: 321 nTPM
myeloid DC: 299 nTPM
classical monocyte: 288 nTPM
T-reg: 267 nTPM

Brain region

choroid plexus: 28 nTPM
hypothalamus: 24 nTPM
medulla oblongata: 20 nTPM
thalamus: 19 nTPM
midbrain: 18 nTPM
spinal cord: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.55
gnomAD pLI: 0
gnomAD missense Z: 0.25
DepMap mean gene effect: 0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PLP2 as an antibody target. Whether an autoantibody or antibody against PLP2 could matter depends on whether native PLP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PLP2 is annotated at the cell surface, where native PLP2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PLP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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